Biodegradable sustained-release medicament stent for TMR and preparation method

Abstract

The invention discloses a transmural myocardial revascularization biodegradable drug controlled-release bracket and a preparation method thereof. The transmural myocardial revascularization biodegradable drug controlled-release bracket comprises a hollow tube with the inner diameter of 0.2mm to 1mm, the wall thickness of 0.1 to 0.5mm and the length of 0.1 to 0.5mm, the wall of the tube is provided with a hole that runs through the wall, and the material of the tube is biodegradable polymer that is loaded with cell growth factors and / or heparin. The bracket of the invention can prevent the hole channel of transmural myocardial revascularization (TMR) from closing and keep the blood flow perfusion unobstructed; the bracket can be degraded into micro molecules to be excreted to the outside of the body shortly after the supporting function and drug-controlling function are completed, thus avoiding adverse impact caused by staying in the body for a long time; the drug controlled-release growth factors can promote the revascularization and the heparin has the function of anticoagulation, thus being beneficial to the restoration of partial ischemic myocardium.

Description

technical field [0001] The invention relates to a biodegradable stent and a preparation method thereof, in particular to a biodegradable drug slow-release stent for revascularization of transmural myocardial blood vessels and a preparation method thereof. Background technique [0002] Transmural myocardial revascularization (TMR) is a new surgical technique for refractory angina pectoris through transmural myocardial perforation using laser or mechanical methods. It is primarily indicated for the treatment of patients with advanced angina pectoris who are undergoing coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) indications. Its role in reducing angina pectoris, improving ischemic myocardial perfusion, and improving heart function has been widely concerned. Recent studies have shown that after TMR, the transmural myocardial vascular channels are occluded due to blood coagulation, which cannot be kept open for a long time, and...

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