Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating

A technology of acylating chitosan and magnesium alloy stents, which is applied in the field of biodegradable vascular stents, can solve the problems of accelerating the initial degradation rate of magnesium alloy substrates, showing acidity, etc., and achieves good collateral passage, intracellular inflammatory response, The effect of unobstructed blood perfusion
CN102488932AInactive Publication Date: 2012-06-13HARBIN ENG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HARBIN ENG UNIV
Publication Date
2012-06-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a magnesium alloy support coated with an acylated chitosan and polyester blend medicine coating. The support comprises a magnesium alloy bare support, the magnesium alloy bare support comprises at least two annular units formed by cylindrical rods in a sine 'peak-valley' shape, the annular units are connected on the axial direction through a link round rod to form a net structure, a blend medicine eluting type coating composed of acylated chitosan, polyester and medicine is coated on the surface of the magnesium alloy bare support. According to the invention, biological medical chitosan and polyester blend material are taken as a support surface coating to improve the biological compatibility, and the coating carries a medicine with restenosis resistance function, thereby the release speed of the medicine can be controlled, and the treatment purpose can be achieved. The magnesium alloy support coated with the acylated chitosan and polyester blend medicine coating possesses good collateral passing ability and flexibility, good radial supporting performance, and is capable of keeping perfusion smoothness of blood flow, effectively delaying the degradation time of the magnesium alloy support, controlling the release of the medicines, and reducing the incidence rate of acute and subacute thrombus after the support is implanted.
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Description

technical field

[0001] The invention relates to a biomedical material, in particular to a biodegradable vascular stent. Background technique

[0002] Since the 1980s, people have successfully used percutaneous angioplasty (Percutaneous Transluminal Coronary Angioplasty PTCA) to treat cardiovascular diseases and achieved certain curative effects. However, PTCA also has application limitations, such as the operation will cause new trauma to blood vessels, which will eventually lead to the incidence of postoperative restenosis and acute vascular occlusion. Based on this situation, cardiovascular disease experts have studied the implantation of bare metal stents at the same time of PTCA surgery to make up for the unsatisfactory problems of PTCA treatment. So far, coronary stent implantation has been a mature and common technique in the field of treating cardiovascular diseases, which can significantly reduce the rate of restenosis. However, most of the widely used vascular ste...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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