Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating

A technology of acylating chitosan and magnesium alloy stents, which is applied in the field of biodegradable vascular stents, can solve the problems of accelerating the initial degradation rate of magnesium alloy substrates, showing acidity, etc., and achieves good collateral passage, intracellular inflammatory response, The effect of unobstructed blood perfusion

Inactive Publication Date: 2012-06-13
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, most of the selected polymers are polylactic acid, etc. During the degradation process, the microenvironment of the matrix is ​​likely to be acidic, and the acidic environment will obviously accelerate the initial degradation rate of the magnesium alloy matrix.

Method used

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  • Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating
  • Magnesium alloy support coated with acylated chitosan and polyester blend medicine coating

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Experimental program
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specific Embodiment approach 1

[0026] Specific embodiment one: first in methanesulfonic acid medium, lauryl chloride and chitosan unit (molecular weight is 200000) are reacted with molar ratio as the ratio of 5: 1 to prepare acylated chitosan OCS, according to PLLA / OCS =30% ratio Dissolve the two blending components in an organic solvent to prepare a homogeneous polymer solution. According to the ratio of drug: polymer drug-loaded material = 10% to 30%, the drug is added to the polymer solution, and a certain volume of organic solvent is added to prepare a uniform coating solution with a certain concentration. Finally, a single-layer drug coating is prepared by ultrasonic atomization and spraying. The drug is one or a combination of drugs with anti-restenosis function including paclitaxel, rapamycin, dactinomycin, emodin, etc. The process parameters to obtain the best coating solution atomization effect are: the solution concentration is 1%, the power of the ultrasonic generator is 0.8, the injection speed...

specific Embodiment approach 2

[0030] Specific embodiment two: experimental condition and operation process are identical with specific embodiment one, just change in the acylated chitosan preparation process, lauryl chloride and chitosan unit (molecular weight is 200000) are the ratio of 5: 1 with molar ratio The reaction is carried out, the two blending components are dissolved in an organic solvent according to the ratio of PLLA / OCS=20%, and finally a single-layer drug coating is prepared by an ultrasonic atomization spraying method. Finally, the drug-eluting stent coating of acylated chitosan-polyester blend was characterized. The experimental results show that the hemolysis rate is 2.17%, but all values ​​are less than the critical value of 5%, indicating that these materials do not produce obvious hemolysis when they come into contact with blood, and all meet the requirements of the hemolysis rate of biological materials. When the time reaches 60 minutes, the OD value is about 0.31, which is still gre...

specific Embodiment approach 3

[0031] Specific embodiment three: experimental condition and operation process are identical with specific embodiment one, just change in the preparation process of acylated chitosan, lauryl chloride and chitosan unit (molecular weight is 200000) are the ratio of 5: 1 with molar ratio The reaction is carried out, the two blending components are dissolved in an organic solvent according to the ratio of PLLA / OCS=10%, and finally a single-layer drug coating is prepared by an ultrasonic atomization spraying method. Finally, the drug-eluting stent coating of acylated chitosan-polyester blend was characterized. The experimental results show that the hemolysis rate is 2.46%, but all the values ​​are less than the critical value of 5%, indicating that these materials do not produce obvious hemolysis when they come into contact with blood, and all meet the requirements for the hemolysis rate of biological materials. When the time reaches 60 minutes, the OD value is about 0.32, which is...

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Abstract

The invention provides a magnesium alloy support coated with an acylated chitosan and polyester blend medicine coating. The support comprises a magnesium alloy bare support, the magnesium alloy bare support comprises at least two annular units formed by cylindrical rods in a sine 'peak-valley' shape, the annular units are connected on the axial direction through a link round rod to form a net structure, a blend medicine eluting type coating composed of acylated chitosan, polyester and medicine is coated on the surface of the magnesium alloy bare support. According to the invention, biological medical chitosan and polyester blend material are taken as a support surface coating to improve the biological compatibility, and the coating carries a medicine with restenosis resistance function, thereby the release speed of the medicine can be controlled, and the treatment purpose can be achieved. The magnesium alloy support coated with the acylated chitosan and polyester blend medicine coating possesses good collateral passing ability and flexibility, good radial supporting performance, and is capable of keeping perfusion smoothness of blood flow, effectively delaying the degradation time of the magnesium alloy support, controlling the release of the medicines, and reducing the incidence rate of acute and subacute thrombus after the support is implanted.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a biodegradable vascular stent. Background technique [0002] Since the 1980s, people have successfully used percutaneous angioplasty (Percutaneous Transluminal Coronary Angioplasty PTCA) to treat cardiovascular diseases and achieved certain curative effects. However, PTCA also has application limitations, such as the operation will cause new trauma to blood vessels, which will eventually lead to the incidence of postoperative restenosis and acute vascular occlusion. Based on this situation, cardiovascular disease experts have studied the implantation of bare metal stents at the same time of PTCA surgery to make up for the unsatisfactory problems of PTCA treatment. So far, coronary stent implantation has been a mature and common technique in the field of treating cardiovascular diseases, which can significantly reduce the rate of restenosis. However, most of the widely used vascular ste...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61F2/90
Inventor 李莉郑玉峰李新林李珍刘西伟候理达
Owner HARBIN ENG UNIV
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