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Non-invasive MRI measurement of tissue glycogen

A glycogen and monosaccharide technology, applied in the fields of biology and medicine, can solve problems such as imprecise spatial recognition rate and weak magnetic resonance signal

Inactive Publication Date: 2009-01-28
THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE +1
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  • Abstract
  • Description
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Problems solved by technology

However, these methods have some drawbacks
For the above two methods, 13 A low concentration of C atoms often results in imprecise spatial discrimination and weak MR signals

Method used

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  • Non-invasive MRI measurement of tissue glycogen
  • Non-invasive MRI measurement of tissue glycogen
  • Non-invasive MRI measurement of tissue glycogen

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Embodiment Construction

[0025] The methods disclosed herein for the spatially resolved detection, imaging, or mapping of glycogen or glucose using magnetic resonance leverage several advantageous aspects of the human body and other typical biological systems containing glycogen or glucose. One of these aspects is that the human body is mainly composed of water. Therefore, MRI data acquired at the water proton MRI frequency usually yield a strong signal and signal-to-noise ratio. (In contrast, magnetic resonance-based imaging such as 13C typically yields substantially lower signal and signal-to-noise ratios.)

[0026] On the other hand, glucose or glycogen molecules at normal body pH levels (eg pH about 7.0-7.3) and at other pH levels such as those that can occur during ischemia (pH about 5.5-7.0) The link between the number or pool of water molecules and the number or pool of water molecules. These numbers are related by proton exchange between water molecules and the protons of the hydroxyl (OH) g...

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Abstract

In a method for deriving information about a selected monosaccharide or polysaccharide such as glucose or glycogen, a selected modification such as saturation is made of magnetic resonance at a magnetic resonance frequency of protons of hydroxyl groups of the selected monosaccharide or polysaccharide. Probative water proton magnetic resonance data are acquired while the selected modification is substantially in effect. Information is derived about concentration or density of the selected monosaccharide or polysaccharide based at least on the probative water proton magnetic resonance data.

Description

technical field [0001] The following relates to the fields of biology and medicine. The invention is described using the example of in vivo spatially resolved detection, imaging, or mapping of glycogen in human tissue. However, the following is more broadly directed to the spatially resolved detection, imaging, or mapping of endogenous glycogen in various types of plant, animal, human, or other biological tissues or samples. Background technique [0002] Glucose is a monosaccharide, or simple sugar. Glycogen is a polysaccharide composed of glucose building blocks. Glycogen is the main form of energy storage in the body. Normally, glucose is ingested in pure form or produced during digestion and can be present in large quantities in the stomach. After absorption and transport into the blood, glucose can be transferred to tissues where it is used as a direct source for metabolism or stored as a polysaccharide such as glycogen. Stored glycogen can be metabolized to release...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/485G01N24/08
CPCG01R33/485G01N24/08
Inventor 彼得·C·M·范西尔克雷格·K·琼斯
Owner THE JOHN HOPKINS UNIV SCHOOL OF MEDICINE
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