Sodium cholate coated liposoluble medicament metacortandracin intercalation hydrotalcite and preparation method thereof
A fat-soluble drug, prednisone technology, applied in the field of adrenal cortex hormone drugs, to achieve the effect of effective storage
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[0019] Step A: Weigh 1.72g of cholic acid and dissolve it in 150ml to remove CO 2 in deionized water, fully stirred to obtain solution I; weigh 0.03g prednisone and dissolve it in 20ml chloroform to obtain solution II; add solution II to solution I, N 2 Protect, volatilize chloroform 4-5 hour, be that chloroform volatilizes completely when seeing that solution becomes transparent, obtain the aqueous solution of required sodium cholate micelles inclusion prednisone.
[0020] Step B: take by weighing 1.80g Mg(NO 3 ) 2 ·6H 2 O and 1.32g Al(NO 3 ) 3 9H 2 O dissolved in 25ml to remove CO 2 , deionized water to prepare a mixed salt solution, and another 0.84g NaOH was dissolved in 25ml to remove CO 2 , deionized water to obtain an alkali solution; the solution obtained in step A is placed in a four-necked flask, and the double-drop co-precipitation method is used in a water bath at 70 ° C under N 2 Add the salt solution and alkali solution dropwise to the solution obtained i...
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