Compound niacin norfloxacin injection and preparation method

Abstract

The invention discloses a compound norfloxacin nicotinate injection which is applicable to the treatment of bacterial gastrointestinal infection of pigs, cattle, sheep and horses, and a preparation method thereof. The compound norfloxacin nicotinate injection is composed of 80-150 parts of norfloxacin nicotinate, 20-80 parts of apramycin sulfate and 5-30 parts of scopolamine hydrobromide. The preparation method is as follows: the components are weighted according to the weight, 300 parts of water for injection are taken, and the norfloxacin nicotinate, the scopolamine hydrobromide and the apramycin sulfate are sequentially added for stirring and dissolution; the mixture is maintained for 15 -20min, the pH value is regulated to 5.0-7.0, and the water for injection is added till 1000 parts after the clarification of liquid medicine for the preparation. The compound preparation is effective and has high efficiency for bacterial diarrhoea of pigs, cattle, sheep and horses, and the compound preparation can treat both manifestation and root cause of disease and alleviate the body stress reaction of affected animals.

Description

technical field [0001] The invention relates to the field of pharmaceutical injections, in particular to a compound norfloxacin nicotinic acid injection suitable for treating bacterial gastrointestinal tract infections in pigs, cattle, sheep and horses and a preparation method thereof. Background technique [0002] Bacillary dysentery is a highly susceptible disease to pigs, cattle, sheep, and horses. It can cause dehydration, weakness, poor growth, and even death in pigs, cattle, sheep, and horses. [0003] The main pathogenic bacteria of this disease are Salmonella, Listeria, etc. Under normal circumstances, these bacteria have long-term residence in livestock. In the event of reduced strength, these bacteria have the potential to become pathogenic and cause infection in livestock, resulting in severe diarrhoea. Over the years, streptomycin and quinolones have been listed as the first-selected drugs for the treatment of bacillary dysentery infection in pigs, cattle, sheep...

AI Technical Summary

Problems solved by technology

[0003] The main pathogenic bacteria of this disease are Salmonella, Listeria, etc. Under normal circumstances, these bacteria have long-term residence in livestock. In the case of reduced strength, these bacteria may become pathogenic bacteria causing livestock infection, resulting in severe diarrhea

Over the years, streptomycin and quinolones have been listed as the first-selected drugs for the treatment of bacillary dysentery infection in pigs, cattle, sheep, and horses all over the world. Due to the long-term repeated use of an antibiotic or antibacterial drug, the pathogenic microorganisms have a great impact on the drug. Strong drug resistance, reduced curative effect, excessive drug residues