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Patch preparation

A preparation and patch technology, applied in the field of patch preparations, can solve the problem of not disclosing polyhydric alcohol fatty acid esters, not disclosing the use of polyhydric alcohols, reducing the area of ​​patches and tablets, and failing to satisfactorily achieve long-term adhesion, etc. problem, to achieve the effect of excellent release ability and inhibition of crystallization

Active Publication Date: 2009-04-22
NITTO DENKO CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] JP-B-7-98744 discloses patch preparations containing fatty acid esters of polyhydric alcohols, monohydric alcohols and cross-linked polyvinylpyrrolidone, but does not disclose the use of polyhydric alcohols
[0007] In addition, the aforementioned prior art does not disclose a polyol fatty acid ester containing at least one hydroxyl group of a polyol, in which area reduction and long-term adhesion of patch tablets are not satisfactorily achieved.

Method used

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  • Patch preparation

Examples

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Comparison scheme
Effect test

Embodiment 1

[0091] By adding n-hexane to Adhesive A (73.6 parts), di(propylene glycol) (3 parts), propylene glycol monolaurate (3 parts), oleyl alcohol (5 parts), isopropyl myristate (5 parts ) and cross-linked polyvinylpyrrolidone (Kollidon CL-M, produced by BASF, 10 parts), and then estradiol (0.4 parts) was added to obtain a coating solution. A polyester film (thickness 75 μm) was coated with this coating solution so that the thickness after drying became 160 μm, and the coating layer was dried. The coated film was adhered to a polyester film (thickness 12 μm), and the resulting film was punched out 5 cm 2 sheet, to obtain the patch preparation of the present invention.

Embodiment 2

[0093] In addition to adding binder A (71.6 parts), di(propylene glycol) (5 parts), propylene glycol monolaurate (3 parts), oleyl alcohol (5 parts), isopropyl myristate (5 parts) and In the mixture of polyvinylpyrrolidone (Kollidon CL-M, produced by BASF, 10 parts), n-hexane was added, and then estradiol (0.4 parts) was added to obtain the coating solution. In the same manner as in Example 1, this product was obtained. Invented patch preparation.

Embodiment 3

[0095] In addition to adding adhesive A (78.6 parts), di(propylene glycol) (3 parts), propylene glycol monolaurate (3 parts), oleyl alcohol (5 parts) and cross-linked polyvinylpyrrolidone (Kollidon CL-M, BASF Production, 10 parts) of the mixture was added n-hexane, followed by adding estradiol (0.4 parts) to obtain a coating solution, in the same manner as in Example 1, to obtain the patch preparation of the present invention.

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Abstract

The present invention aims at provision of a patch preparation having a small area and permitting adhesion for a long time. The present invention provides a patch preparation having an adhesive layer on at least one surface of a support, wherein the adhesive layer contains an adhesive, a poorly soluble drug, a first organic liquid component, a second organic liquid component, a third organic liquid component and crosslinked polyvinylpyrrolidone, the solubility of the poorly soluble drug in the first organic liquid component is not less than the solubility of the poorly soluble drug in the second organic liquid component, and the solubility of the poorly soluble drug in the second organic liquid component is not less than the solubility of the poorly soluble drug in the third organic liquid component.

Description

technical field [0001] The present invention relates to a patch preparation provided with an adhesive layer on at least one surface of a support. Background technique [0002] As an excellent drug delivery method with many advantages, such as drug absorption in the gastrointestinal tract and avoiding the first pass effect of the drug in the liver, it is difficult to swallow the drug. Superiority for patients, prevention of forgetting to administer medication, etc., and various types of patch preparations have been developed. [0003] Improvement in QOL (Quality of Life), which has attracted attention over the years, is also considered to be very necessary for patch preparations. Therefore, there is a need to reduce the area of ​​patch preparations to reduce stress during adhesion, and to satisfy long-term adhesion to reduce problems of patch replacement and skin irritation. Related prior art is as follows. [0004] JP-A-8-104625 discloses patch preparations containing pol...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70
CPCA61K9/7053A61K47/10A61K47/32A61P15/12
Inventor 井之阪敬悟田村圭吉野修
Owner NITTO DENKO CORP