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Uses of rhodiola rosea in preventing and treating insulin resistance, and correlated metabolism diseases

A technology for insulin resistance and metabolic diseases, which is applied in the field of Rhodiola for the prevention and treatment of insulin resistance and related metabolic diseases, and can solve the problems of high incidence of adverse reactions, stimulation, application restrictions, etc.

Inactive Publication Date: 2009-05-13
INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this type of drug has been used to treat diabetes in the late 1950s, the incidence of adverse reactions is very high, mainly including obvious digestive side effects such as gastrointestinal irritation and lactic acid poisoning, which limit its application

Method used

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  • Uses of rhodiola rosea in preventing and treating insulin resistance, and correlated metabolism diseases
  • Uses of rhodiola rosea in preventing and treating insulin resistance, and correlated metabolism diseases
  • Uses of rhodiola rosea in preventing and treating insulin resistance, and correlated metabolism diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1. Effect of Rhodiola Rosea Extract on Insulin Tolerance in Insulin-resistant IR Mice

[0047] method:

[0048] C57BL mice were fed with high-fat and high-sugar diet to form insulin resistance mouse model (IR). The model animals were randomly divided into 3 groups, respectively the model animal control group (IR), the positive control drug rosiglitazone group (rosiglitazone), and the Rhodiola rosea extract group, respectively oral water, rosiglitazone 15mg / kg, and Rhodiola rosea extract 2g / kg. At the same time, the same batch of normal animals fed with normal feed were set as the normal control group (Con). Inject 0.4U / kg insulin subcutaneously to the animals, observe the change of blood glucose after insulin loading, and calculate the area under the blood glucose-time curve (AUC), that is, the insulin tolerance test (ITT).

[0049] result:

[0050] Insulin-resistant animals were administered continuously for 10 days, and ITT experiments were carried out. ...

Embodiment 2

[0051] Example 2. Effect of Rhodiola rosea extract on oral glucose tolerance in insulin resistant IR mice

[0052] method:

[0053] C57BL mice were fed with high-fat and high-sugar diet to form insulin resistance mouse model (IR). The model animals were randomly divided into 3 groups, respectively model animal control group (IR), rosiglitazone group, and Rhodiola rosea extract group, respectively oral water, positive control drug rosiglitazone 15mg / kg, and Rhodiola rosea extract group. Daily extract 2g / kg. At the same time, the same batch of C57BL mice were fed with normal feed as the normal control group (Con). After continuous administration for 7 days, 2 g / kg of glucose was administered orally to animals, and the changes of blood glucose after glucose loading were observed, and the area under the blood glucose-time curve (AUC) was calculated, namely oral glucose tolerance test (OGTT).

[0054] result:

[0055] The results show that( image 3) , Compared with Con, the b...

Embodiment 3

[0056] Example 3. Effect of Rhodiola Rosea Extract on Glucose Infusion Rate GIR at Steady State in Ecglucose Clamp Experiment of Insulin Resistance IR Mice

[0057] method:

[0058] C57BL mice were fed with high-fat and high-sugar diet to form insulin resistance mouse model (IR). The model animals were randomly divided into 3 groups, respectively model animal control group (IR), rosiglitazone group, and Rhodiola rosea extract group, respectively oral water, positive control drug rosiglitazone 15mg / kg, and Rhodiola rosea extract group. Daily extract 2g / kg. At the same time, the same batch of C57BL mice were fed with normal feed as the normal control group (Con). Continuously administered for 20-25 days, a hyperinsulinemic clamp (orthoglycemic clamp) experiment with normal glucose levels was performed. That is, the animals were fasted for 4 hours, weighed, anesthetized by intraperitoneal injection of pentobarbital sodium, fixed on a 37°C constant temperature plate, surgically...

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Abstract

The invention discloses a Rhodiola L. and the application of the extract thereof as the drug used for preparing the insulin resistance and preventing and curing the relative metabolic diseases of diabetes, adiposis and the like; meanwhile, the invention discloses a preparation method for the extract; in addition, the invention further discloses the application of a pharmaceutical composition including the Rhodiola L. or (and) the Rhodiola L. extract as the drug and the health care product, and particularly discloses the application of the pharmaceutical composition used for preparing the drugs and the health care products for curing and preventing the insulin resistance and the relative metabolic diseases of diabetes, adiposis and the like.

Description

technical field [0001] The present invention relates to extracting an extract capable of increasing insulin sensitivity from a plant of the genus Rhodiola, a preparation method of the extract, a pharmaceutical composition containing a plant of the genus Rhodiola or an extract of the genus, and a plant of the genus Rhodiola Or the use of the genus extract and its pharmaceutical composition as medicine, especially for the preparation of medicines and health products for treating and preventing insulin resistance and related metabolic diseases such as diabetes and obesity. Background technique [0002] Insulin resistance refers to the reduced sensitivity and / or responsiveness of the body to insulin, which is the main pathophysiological basis of metabolic syndrome, and is related to impaired glucose tolerance, type 2 diabetes and its complications, obesity, dyslipidemia, Clinical abnormalities such as non-alcoholic fatty liver disease and coronary heart disease are closely relat...

Claims

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Application Information

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IPC IPC(8): A61K36/41A61P5/50A61P3/10A61P3/04A61K125/00
Inventor 叶菲张培成田金英冯子明陶荣亚丛维娜刘倩吴倩牛亚景杨桠楠
Owner INST OF MATERIA MEDICA AN INST OF THE CHINESE ACAD OF MEDICAL SCI
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