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Integrated atomizing freeze drying equipment and method

A technology of spray freeze drying and spray freezing, applied in the field of products, can solve the problems of cumbersome, prone to accidents, time-consuming and laborious, and achieve the effect of reducing operation risks, strengthening occupational safety protection, and simple and easy operation procedures.

Inactive Publication Date: 2009-05-27
MACAO POLYTECHNIC INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This process is very cumbersome, time-consuming and labor-intensive, and it is not conducive to the application of spray freeze-drying technology in large-scale industrial production; when handling and moving refrigerated liquids, such as liquid nitrogen, it is easy to cause physical damage to users, and accidents are prone to occur

Method used

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  • Integrated atomizing freeze drying equipment and method
  • Integrated atomizing freeze drying equipment and method
  • Integrated atomizing freeze drying equipment and method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] figure 1 It is a structural schematic diagram of Embodiment 1 of the present invention. The freeze-drying chamber of this embodiment is cooled by a freezing device 11 , and the freeze-drying chamber is composed of a frozen particle storage chamber 30 and a freezing chamber 40 that communicate with each other, and the frozen particle storage chamber 30 is located above the freezing chamber 40 . The frozen particle containing chamber 30 is provided with a nebulizer 1 and a refrigerant inlet 5 . The material liquid source 15 is connected with the sprayer 1 through the pipeline 23, and the material liquid is pumped into the sprayer 1 by the peristaltic pump 14. The peristaltic pump 14 can adopt the MASTER flex L / S of Cole-Parmer Instrument Company, and the peristaltic pump 14 can use different thickness soft The adjustable flow rate range is large, the flow is stable, and the pulse is not obvious; at the same time, the high-pressure gas source 18 is connected to the spraye...

Embodiment 2

[0046] figure 2 It is a structural schematic diagram of Embodiment 2 of the present invention, and external equipment such as a vacuum pump, high-pressure gas source, refrigerated liquid tank, peristaltic pump, and hot water circulator are the same as Embodiment 1, and will not be described in detail here.

[0047] Such as figure 2 As shown, the freeze-drying chamber of this embodiment is composed of a frozen particle storage chamber 50 and a freezing chamber 60 that communicate with each other, and the frozen particle storage chamber 50 is located on the left side of the freezing chamber 60 . The sprayer 1, the helical agitator 2, the environmental parameter sensor 4 and the freezing liquid inlet 5 are located in the freezing particle containing chamber 50, and they work together to realize the spray freezing of the feed liquid as in the first embodiment. The right side of the frozen particle holding chamber 50 is provided with a communication port 51 communicating with th...

Embodiment 3

[0049] image 3 It is a structural schematic diagram of Embodiment 3 of the present invention, and the external equipment such as vacuum pump, high-pressure air source, refrigerated liquid tank, peristaltic pump and hot water circulator are the same as Embodiment 1, and will not be described in detail here.

[0050] Such as image 3As shown, the biggest difference between the present embodiment and the first and second embodiments is that the spray freezing chamber 70 is separated from the freeze-drying chamber 80, and the communication port between them is provided with valve devices such as baffle plate 26, but still can Make the operation complete in one step, simple and easy. The sprayer 1, the spiral agitator 2 and the cooling liquid inlet 5 are located in the spray freezing chamber 70 for spray freezing, and the environmental parameter sensor 4 is installed in the freeze drying chamber 80, and the baffle 26 is closed at this time. After the spraying is completed, the t...

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Abstract

The invention relates to an integral spray refrigeration drying device and a method thereof, belonging to novel solid dispersoid preparation technique. The device comprises a refrigeration drying chamber for carrying out cooling by a refrigeration device, the refrigeration drying chamber is provided with a vacuum pumping opening, a liquid outlet, a sprayer and a refrigerant inlet, and the sprayer is connected with a liquid material source. The method comprises a spray refrigeration step and a refrigeration drying step which automatically proceed in a same device successively. The spray refrigeration device and the refrigeration drying device are integrated to make the spray refrigeration step and the refrigeration drying step proceed in same device. The refrigeration drying step can be carried out without manually transferring frozen granules after the spray refrigeration step is finished, thereby realizing operation integration and automation. The whole processing flow is easy and simple, operation danger is reduced, safety protection is strengthened, and industry automation can be realized.

Description

technical field [0001] The invention relates to spray freeze-drying equipment and a method, which belongs to a new solid dispersion preparation technology and is mainly used for high value-added products such as water insoluble medicines and biotechnology products. Background technique [0002] At present, solid dispersion preparation technology is widely used in the field of pharmaceutical research. This technology is realized by changing the crystal shape, particle size, porosity and specific surface area of ​​the material particles. Traditional solid dispersion preparation techniques include melting, solvent, grinding, freeze-drying, and spray-drying methods. The melting method needs to form a supersaturated solution, the solvent method needs a large amount of rapid volatilization of the solvent, and the spray drying method needs to dry the drug-loaded droplets instantaneously. These three methods require higher temperatures, which will accelerate the degradation of the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): F26B17/10F26B5/06
Inventor 唐海谊杜祯黎畅明郑颖
Owner MACAO POLYTECHNIC INST
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