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Double-medication combined bracket

A dual-drug and stent-based technology, applied in the field of dual-drug combined stents, can solve the problems of prolonged endothelialization time at the injury site, lack of anti-proliferative effect of rapamycin, and difficulty in healing at the injury site, thereby inhibiting the proliferation of vascular smooth muscle cells, Avoiding inflammation and side effects, inhibiting the effect of restenosis

Inactive Publication Date: 2009-06-03
LEPU MEDICAL TECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Due to the lack of selectivity of the anti-proliferation effect of rapamycin, the drug also inhibits the normal recovery of endothelial cells while inhibiting the proliferation of smooth muscle cells, which prolongs the endothelialization time of the injured part, makes it difficult to heal the injured part, and there is a late inflammatory reaction, which is easy to delayed stent thrombosis

Method used

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  • Double-medication combined bracket

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of double-drug stent sprayed with rapamycin first and then with probucol

[0036] Prepare the 316L stainless steel bare stent with nanopores (100nm~1um), weigh rapamycin and dissolve it in tetrahydrofuran to make a 2% solution, then spray it with a sprayer, then weigh probucol and dissolve it in Prepare a 6% solution in tetrahydrofuran, and spray the probucol solution after the tetrahydrofuran sprayed on the bracket for the first time is evaporated, and the preparation is completed after being evaporated.

[0037]After testing, the loading amount of rapamycin on the stent is 100±50ug / support, and the loading amount of probucol on the stent is 300±50ug / support.

[0038] From figure 1 and figure 2 The surface of the stent can be seen by scanning electron microscopy, and the pores on the surface of the stent have a good physical adsorption effect on the dual drugs.

Embodiment 2

[0040] A double-drug stent was prepared by spraying rapamycin first and then a mixed solution of rapamycin and probucol.

[0041] Prepare the 316L stainless steel bare stent with nanopores, weigh rapamycin and dissolve it in tetrahydrofuran to make a 2% solution, spray it on the stent with a sprayer, and weigh rapamycin after it is evaporated to dryness. and probucol are dissolved and mixed with tetrahydrofuran solution to form a 4% solution, and then sprayed on the stent and evaporated to dryness to complete the preparation.

[0042] After testing, the loading amount of rapamycin on the stent is 500±80ug / support, and the loading amount of probucol on the stent is 200±50ug / support.

Embodiment 3

[0044] Preparation of double-drug stents soaked in the mixed solution of rapamycin and probucol, and then sprayed with rapamycin

[0045] Prepare a 316L stainless steel bare stent with nanopores prepared, weigh rapamycin and probucol, dissolve and mix them with tetrahydrofuran solution to make a 10% solution, soak the stent in the solution for 30 minutes, take it out and evaporate it to dryness , and then weigh rapamycin and dissolve it in tetrahydrofuran to form a 5% solution, spray it on the stent, and complete the preparation after it is evaporated to dryness.

[0046] After testing, the loading amount of rapamycin on the stent is 600±50ug / support, and the loading amount of probucol on the stent is 150±50ug / support.

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Abstract

The invention provides a novel double-medication combined bracket which adopts hole physical adsorption to directly coat the surface of the bracket with rapamycin and probucol. The novel double-medication combined bracket can make full use of the complementation of refraining the bracket restenosis mechanism of two medications, restenosis after a surgery is sufficiently refrained, and endothelialization is accelerated; and meanwhile, because a carrier and a substrate are not adopted to coat the surface of the bracket, side effects of inflammation and the like brought by the carrier and the substrate are avoided.

Description

technical field [0001] The invention belongs to the field of medical equipment, and relates to a dual-drug combined stent, which uses hole physical adsorption to directly coat the surface of the stent, and inhibits vascular inflammation after stent implantation through the joint action of two drugs, rapamycin and probucol The induced proliferation of vascular smooth muscle cells reduces the formation of secondary thrombus after surgery; meanwhile, it avoids the possible inflammation and side effects caused by the carrier matrix. Background technique [0002] The current treatment methods for patients with coronary heart disease mainly include drug therapy, pereu-taneous coronary intervention (PCI) and coronary artery bypass graft (CABG). PCI can dredge the coronary artery lumen, increase myocardial blood perfusion, improve the therapeutic effect of coronary heart disease, and reduce the mortality rate of patients with coronary heart disease. It has become an important means ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61M31/00
Inventor 王玲张昱昕张正才蒲忠杰
Owner LEPU MEDICAL TECH (BEIJING) CO LTD