Laser Confocal Microendoscopy

Abstract

The invention discloses a novel high-resolution laser confocal microendoscope, which adopts a telescopic image transmission system instead of an optical fiber bundle or a single optical fiber, couples laser light into tissues in the body, and couples reflected light or fluorescent signals to The in vitro detector reduces the diameter of the endoscopic probe while obtaining high-resolution and contrast fluorescence images; the confocal scanning mechanism is set outside the body to obtain high-performance confocal scanning without increasing the size of the endoscopic probe , and is compatible with existing rigid tube endoscopes, enabling high-performance in vivo histopathological diagnosis.

Description

technical field [0001] The invention belongs to the technical field of medical device manufacturing, in particular to a laser confocal microendoscope. Background technique [0002] Medical endoscope is an essential medical equipment for detection and diagnosis of internal lesions and minimally invasive surgery, and it is widely used in various fields of clinical medicine. Endoscopy observes internal tissues on a macro scale, identifies suspicious areas, and if necessary, clamps suspicious tissues outside the body for histopathological diagnosis, but this is a traumatic process, often accompanied by bleeding, infection, early missed diagnosis, etc. It has certain risks. Laser confocal microendoscopy can realize real-time high-resolution histopathological diagnosis of internal organs without sampling biopsy, and can use fluorescent contrast agent, which has strong specificity. It is an important tool for non-invasive diagnosis of early lesions, especially It is of great sign...

AI Technical Summary

Problems solved by technology

[0003] The current laser confocal microendoscope uses a fiber bundle or a single fiber to introduce laser and fluorescent signals into the body and out of the body respectively. The fiber bundle allows the confocal scanning mechanism to be placed outside the body. The endoscopic probe can be small, but the image The definition is seriously affected by the grid arrangement of the fiber bundle itself, the resolution of the confocal image is low, and the contrast of the image is difficult to improve due to the crosstalk of light from adjacent core diameters; a single fiber requires that the confocal scanning mechanism must be placed in the In the body, although the existing MEMS technology can reduce the size of the scanning mechanism, the current technology cannot take into account the small size and large scanning range; neither the optical fiber bundle nor the single optical fiber can correct the aberration of the endoscopic system

Therefore, the optical design of this type of microendoscope, especially the design of the microscopic objective lens is complex

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