Amikacin desorbed solution concentration method using nano filtration technique

A technology of amikacin and analytical solution, which is applied in the field of concentration of amikacin analytical solution, can solve the problems of low rejection rate of monovalent inorganic salts, reduce energy consumption, shorten reaction time, and increase product yield and quality effects
CN101455941AActive Publication Date: 2009-06-17山东安信制药有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
山东安信制药有限公司
Publication Date
2009-06-17

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Abstract

The invention relates to a method for concentrating Amikacin desorbed solution by nanofiltration technology. The method comprises: firstly, prefiltrating and purifying the Amikacin desorbing solution; and then, feeding the Amikacin desorbing solution into a charging bucket, and concentrating the solution by adopting the nanofiltration technology, wherein the membrane flux of a nanofiltration membrane is between 20 and 40 L / m2h, the pH value of the Amikacin desorbed solution is between 10 and 12, the temperature is between 0 and 40 DEG C, and the pressure at the inlet of the charging bucket is between 0.2 and 2 MPa. The method for concentrating Amikacin desorbed solution overcomes the disadvantages of the prior process including declining product degradation, quality and yield, and ensures that concentration yield can reach 98 percent; moreover, the product has ideal appearance and obviously improved quality after crystallization, and production period is reduced at the same time.
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Description

technical field

[0001] The invention relates to the application of nanofiltration membrane technology in the field of antibiotics, especially the application in the concentration of amikacin analysis solution. technical background

[0002] Amikacin, having the structure shown in formula I, is a semi-synthetic derivative of kanamycin A and is a broad-spectrum antibiotic.

[0003]

[0004] Amikacin I

[0005] There is no method for concentrating the amikacin analysis solution in existing documents and patents. The method commonly used in production is thin film evaporation. Due to the high energy consumption of the thin film evaporation method and the long heating time, the heat-sensitive amikacin product is partially destroyed, the yield is reduced, and the product quality is affected. Thereby be unfavorable for industrialized production.

[0006] With the development of membrane technology, the nanofiltration membrane that appeared in the 1980s filled the gap between ...

Claims

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