Unlock instant, AI-driven research and patent intelligence for your innovation.

Novel method for synthesizing acetyl-sulfisoxazole

A technology for sulfaacetylisoxazole and sodium isoxazole, which is applied in the new preparation field of sulfaacetylisoxazole, can solve the problems of low yield and high cost, and achieves simple operation process, improved product yield and mild reaction conditions Effect

Inactive Publication Date: 2009-06-17
四川省惠达药业有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The product prepared according to the above-mentioned patent has a low yield after repeated tests, and the average yield of 5 batches of samples is only about 50%, and the product that is restricted in use by the second part of the Chinese Pharmacopoeia is used. Anhydrous pyridine, resulting in high product cost

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel method for synthesizing acetyl-sulfisoxazole
  • Novel method for synthesizing acetyl-sulfisoxazole
  • Novel method for synthesizing acetyl-sulfisoxazole

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0020] Embodiment: the preparation of sulfaacetylisoxazole

[0021] Add 26.73 grams of sulfisoxazole and 260 milliliters of deionized water into a 500 milliliter beaker. After stirring evenly, add a solution of 4.0 grams of sodium hydroxide dissolved in 20 milliliters of deionized water, stir at 40-50 °C for 15 minutes, and measure the solution The pH is about 8-9, and it is filtered while it is hot, and the filtrate is left overnight at about 0°C. Suction filtration, wash the filter cake with a small amount of ethanol, and dry at about 50°C to constant weight to obtain about 25.0 g of white powder of sulfisoxazole sodium salt, with a yield of about 93.0%.

[0022] In a three-neck flask equipped with a thermometer, a reflux condenser and a drying tube, add 20 grams of sulfisoxazole sodium salt and 60 milliliters of acetone, stir evenly, raise the temperature to 35-40 ° C, and add acetic anhydride dropwise. After dropping, the reaction was carried out at 35-40° C. with stirrin...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing gantrisinacetyl. The method comprises the steps of preparing sulfafurazole into sodium salt, using acetone as a solvent, using acetic anhydride for acylation and obtaining the gantrisinacetyl. The yield of the method reaches 85 percent.

Description

technical field [0001] The present invention relates to a novel preparation method of sulfaacetylisoxazole. Sulfaacetylisoxazole is a sulfonamide antibiotic. Background technique [0002] Sulfisoxazole Acetyl, also known as sulfisoxazole, is a monoacetylated product of sulfisoxazole. Sulfaisoxazole has an antibacterial activity comparable to that of sulfisoxazole, but it does not have the bitter taste of sulfisoxazole, which is more conducive to making oral preparations. [0003] U.S. Patent 2,721,200 (1955) discloses a kind of preparation method of sulfamethoxazole as follows: [0004] Suspend sulfisoxazole in acetone and add anhydrous pyridine. Under stirring, add acetic anhydride, and the reaction solution should be clear. Raise the temperature to 39-45°C and keep it for 15-30 minutes. Then start to cool down, after being down to room temperature, continue to stir for 5 hours, stop stirring, and the mixture is left for 10 hours. Add ice-cold ammonia water and some f...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07D261/16
Inventor 梁宏毅杨连兵王兰周
Owner 四川省惠达药业有限公司