Preparation of N(2)-L-alanyl-L-glutamine
A technology of glutamine and alanyl, which is applied in the field of preparation of N-L-alanyl-L-glutamine, can solve the problems of high amino acid price and high process cost, and achieves simple process, low cost and low toxicity. Effect
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[0022] 1. Preparation of N(2)-D-α-chloropropionyl-L-glutamine
[0023] Pour 31ml of water and 31ml of toluene into the reaction flask and mix evenly, start stirring, add 10g of L-glutamine, and cool to 5°C. Slowly add 5N sodium hydroxide dropwise to make the pH value of the solution reach 10, and the L-glutamine is completely dissolved. At the same time, 10.6ml of anhydrous toluene containing 8.5g D-α-chloropropionyl chloride and 5N sodium hydroxide were added dropwise to the above solution within 2 hours, and the pH value was adjusted with sodium hydroxide to keep the pH value of the solution at 10. A total of 29.5ml of sodium hydroxide was added twice, and the temperature was kept at 5°C; after the dropwise addition, the stirring was continued for 1 hour while maintaining the temperature at 5°C. Stop stirring then, carry out cooling; Static layering, separate the toluene layer, under room temperature, 12.6g sodium chloride is added in the mixed solution that does not have t...
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