A kind of pleuromutilin extraction process

A technology of pleuromutilin and extraction process, which is applied in the field of extraction process of raw material pleuromutilin mycelium, to achieve the effect of benefiting the health, shortening the production cycle, and improving the economic and social benefits of the enterprise

Inactive Publication Date: 2011-12-21
河北美邦工程科技股份有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a completely closed filtration extraction process of pleuromutilin mycelia used in the production process of tiamectin, so as to solve the problems existing in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of pleuromutilin extraction process
  • A kind of pleuromutilin extraction process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1: as figure 1 As shown, after putting the pleuromutilin mycelia with a water content of 20 to 30% into the extraction tank 1, methanol solvent is added in a ratio of 1:3 to 1:6 in parts by weight, and at room temperature 20 to 40°C After continuous stirring for 3-6 hours under high temperature, the extract solution was made, and then the extract solution was filtered through a ceramic membrane 2 with a pore size of 1 μm-20 nm under a pressure of 0.2-0.6 Mpa through a feed pump 3, wherein the ceramic membrane 2 was made of Jiangsu The ceramic filter membrane with a pore size of 1 μm to 20 nm produced by Jiuwu High-Tech Co., Ltd. or Germany ATECH Technology Development Co., Ltd. sends the filtrate that passes through the ceramic membrane 2 to the subsequent semi-finished product processing system. Lift tank 1, another part of raffinate passes through circulation pump 4 and then circulates and filters through ceramic membrane 2, and controls the ratio of the fl...

Embodiment 2

[0021] Embodiment 2: The difference between this embodiment and Embodiment 1 is that methanol solvent is replaced by ethanol solvent.

Embodiment 3

[0022] Example 3: The difference between this example and Example 1 is that the methanol solvent is replaced by ethanol solvent, and the ceramic membrane is replaced by a stainless steel membrane with a pore size of 1 μm to 50 nm produced by Hebei Ruitong Meibang Engineering Co., Ltd. or Kaimembrane Filtration Technology Co., Ltd. 2 .

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses a process for extracting pleuromutilin in the synthesis process of tiamectin, which comprises mixing pleuromutilin mycelia with methanol or ethanol and continuously stirring at 20-40°C for 3-6 hours. Make the extraction solution; then pass the extraction solution under a certain pressure through the closed inorganic membrane filtration system, and the filtrate is sent to the subsequent processing system, part of the residual solution is returned to the extraction tank, and the other part is circulated through the closed inorganic membrane after passing through the circulation pump. Filtration, adopting the process of the present invention can effectively separate and clarify the pleuromutilin extract, the filtration speed is fast, and the filtration precision is high. Compared with the traditional plate and frame filtration process, the process can be shortened by 6 to 10 hours per day, and the yield can be increased by 5 ~7%, low energy consumption, the use of a closed inorganic membrane filtration system can reduce the loss of organic solvents due to volatilization, and can achieve clean production, which can not only reduce the production cost of the enterprise, but also greatly improve the working environment, which is beneficial to the health of the operator Healthy, with significant socioeconomic benefits.

Description

technical field [0001] The invention relates to the field of veterinary antibiotic production, in particular to an extraction process of pleuromutilin mycelium, a raw material used in the synthesis process of tiamectin. Background technique [0002] Tiamectin is an antibiotic drug, which is produced by fermentation of basidiomycetes to produce pleuromutilin, and then synthesized through sulfonation, acidification and other processes. Tiamectin is mainly used to prevent and treat chronic respiratory diseases in chickens and mycoplasma pneumonia in swine etc., is one of the drugs commonly used in animals. [0003] At present, in the extraction process of pleuromutilin, it is necessary to use plate and frame filtration to remove the liquid in the fermentation broth to obtain mycelia, and then use 3 to 6 times the weight of the mycelium for leaching with an organic solvent, and leaching under constant stirring 3 to 6 hours, then settling for 2 to 4 hours, the primary extraction...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07C69/675
Inventor 王素霞金作宏高文杲张玉新张卫国李华北张志学
Owner 河北美邦工程科技股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap