Process for extracting pleuromulin

A technology for extracting pleuromutilin and its extraction process is applied in the field of extracting process of raw material pleuromutilin mycelium to achieve the effect of benefiting the health, shortening the production cycle, and improving the economic and social benefits of the enterprise

Inactive Publication Date: 2009-07-15
河北美邦工程科技股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] The purpose of the present invention is to provide a completely closed filtration extraction process of pleuromutilin mycelia used in the production process of tiamectin, so as to solve the problems existing in the prior art

Method used

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  • Process for extracting pleuromulin

Examples

Experimental program
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Effect test

Embodiment 1

[0020] Embodiment 1: as figure 1 As shown, after putting the pleuromutilin mycelia with a water content of 20 to 30% into the extraction tank 1, methanol solvent is added in a ratio of 1:3 to 1:6 in parts by weight, and at room temperature 20 to 40°C After continuous stirring for 3-6 hours under high temperature, the extract solution was made, and then the extract solution was filtered through a ceramic membrane 2 with a pore size of 1 μm-20 nm under a pressure of 0.2-0.6 Mpa through a feed pump 3, wherein the ceramic membrane 2 was made of Jiangsu The ceramic filter membrane with a pore size of 1 μm to 20 nm produced by Jiuwu High-Tech Co., Ltd. or Germany ATECH Technology Development Co., Ltd. sends the filtrate that passes through the ceramic membrane 2 to the subsequent semi-finished product processing system. Lift tank 1, another part of raffinate passes through circulation pump 4 and then circulates and filters through ceramic membrane 2, and controls the ratio of the fl...

Embodiment 2

[0021] Embodiment 2: The difference between this embodiment and Embodiment 1 is that methanol solvent is replaced by ethanol solvent.

Embodiment 3

[0022] Example 3: The difference between this example and Example 1 is that the methanol solvent is replaced by ethanol solvent, and the ceramic membrane is replaced by a stainless steel membrane with a pore size of 1 μm to 50 nm produced by Hebei Ruitong Meibang Engineering Co., Ltd. or Kaimembrane Filtration Technology Co., Ltd. 2 .

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Abstract

The invention discloses a process for extracting pleuromutilin in tiamulin synthetic process. The process comprises the following steps: mixing pleuromutilin mycelium with methanol or ethanol, and continuously stirring the mixture at the temperature of 20-40 DEG C for 3-6h to prepare leach liquor; and allowing the leach liquor to pass through a closed inorganic membrane filtering system at a certain pressure, sending the obtained filtrate to a subsequent processing system, allowing part of the residual filtrate to return to a lixiviating tank and the other part thereof to run through a circulating pump for being circularly filtered by the closed inorganic membrane. The process can effectively separate and clarify the pleuromutilin leach liquor, shorten process flow by 6-10h for each day, improve the yield by 5-7% compared with a traditional plate-and-frame filtering process, and has fast filtering rate, high filtering precision and low energy consumption. The closed inorganic membrane filtering system can help reduce the loss of organic solvents caused by volatilization and realize clean production, thus lowering production cost of enterprises, greatly improving working environment, being favorable for health of operators, and having significant social and economic benefits.

Description

technical field [0001] The invention relates to the field of veterinary antibiotic production, in particular to an extraction process of pleuromutilin mycelium, a raw material used in the synthesis process of tiamectin. Background technique [0002] Tiamectin is an antibiotic drug, which is produced by fermentation of basidiomycetes to produce pleuromutilin, and then synthesized through sulfonation, acidification and other processes. Tiamectin is mainly used to prevent and treat chronic respiratory diseases in chickens and mycoplasma pneumonia in swine etc., is one of the drugs commonly used in animals. [0003] At present, in the extraction process of pleuromutilin, it is necessary to use plate and frame filtration to remove the liquid in the fermentation broth to obtain mycelia, and then use 3 to 6 times the weight of the mycelium for leaching with an organic solvent, and leaching under constant stirring 3 to 6 hours, then settling for 2 to 4 hours, the primary extraction...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/675
Inventor 王素霞金作宏高文杲张玉新张卫国李华北张志学
Owner 河北美邦工程科技股份有限公司
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