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Method for preparing total polyphenol of Loropetalum chinense (R. Br.) Oliver for treating burn and scald

A technology for total polyphenols, burns and scalds, which is applied in the field of preparation of total polyphenols of Corydalis chinensis, can solve the problems of short course of treatment, small adverse reactions and the like, and achieves the effect of a simple preparation method

Inactive Publication Date: 2009-07-22
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In China, the main drug dosage forms of conservative therapy are patches and ointments, etc. In addition to Yunnan Baiyao and scalding ointment, there is still a lack of a drug with definite curative effect, short course of treatment, high cure rate, small adverse reactions, and economical convenience in the market

Method used

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  • Method for preparing total polyphenol of Loropetalum chinense (R. Br.) Oliver for treating burn and scald

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Take 5kg of shade-dried loropetalum leaves, crush them, put them into a multifunctional extraction tank, add 8 times the amount of 70% acetone to soak at room temperature for 1 day, filter, and put the filtrate into the concentration tank; add 8 times the amount of 70% acetone to soak at room temperature for the filter residue Extract 3 times, soak for 1 day each time, filter, pour the filtrate into a concentration tank, combine with the first extraction and concentrate in vacuo, recover acetone and concentrate until the crude drug:water volume ratio is 2:1, and the column liquid is obtained.

[0020] (2) According to crude drug: resin volume ratio = 1: 1, add the upper column solution obtained by extraction on the D101 type macroporous adsorption resin column that has been processed, and use 10% dilute ethanol to elute until the eluent is nearly empty. Then use 30% ethanol to elute the resin column until the eluent is nearly colorless, collect the 40% ethanol eluate...

Embodiment 2

[0022] (1) Take 7kg of fresh loropetalum leaves, crush them, put them into a multi-functional extraction tank, add 20 times the amount of 20% acetone to soak at room temperature for 10 days, filter, and pour the filtrate into the concentration tank; add 15 times the amount of 70% acetone at room temperature to the dregs Soak for 10 days, filter, pour the filtrate into a concentration tank, combine with the first extract and concentrate in vacuo, recover acetone and concentrate until the crude drug:water volume ratio is 1:1, and the column liquid is obtained.

[0023] (2) According to crude drug: resin volume ratio = 3: 1, add the upper column liquid obtained in the extraction section to the HPD100 type macroporous adsorption resin column that has been treated, and wash with water until the eluent is nearly colorless, and then use The resin column was eluted with 60% ethanol until the eluate was nearly colorless, and the 60% ethanol eluate was collected, and the ethanol was reco...

Embodiment 3

[0025] (1) Take 10kg of fresh loropetalum leaves, crush them, put them into a multifunctional extraction tank, add 10 times the amount of 30% acetone to soak at room temperature for 7 days, filter, and pour the filtrate into the concentration tank; add 8 times the amount of 30% acetone at room temperature to the dregs Soak and extract twice, each time for 7 days, filter, put the filtrate into a concentration tank, combine with the first extract and concentrate in vacuo, recover acetone and concentrate until the crude drug:water volume ratio is 1.5:1, and the column liquid is obtained.

[0026] (2) According to the crude drug: resin volume ratio = 2: 1, add the upper column liquid obtained in the extraction section to the HP20 type macroporous adsorption resin column that has been treated, and wash it with water until the eluent is nearly colorless, and then use The resin column was eluted with 40% ethanol until the eluate was nearly colorless, the 40% ethanol eluate was collect...

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Abstract

The invention discloses a method for preparing loropetalum chinense total polyphenol for treating burn and scald, and relates to a drug for treating the burn and scald. The invention provides the method for preparing the loropetalum chinense total polyphenol for treating the burn and scald, which comprises that: Loropetalum chinense leaves are pulverized, are added with acetone, are soaked, and are filtered to obtain filtrate and filter residue; the filter residue is added with the acetone, is soaked, is extracted for at least one time, and is filtered; the filtrate is combined and is condensed to obtain an upper column solution; the acetone is reclaimed; the upper column solution is added to a macroporous resin column and is eluted with water or ethanol till an eluant is close to colorless; the eluant is collected; and the ethanol is reclaimed is condensed, and is dried to obtain the loropetalum chinense total polyphenol. The preparation method is simple and suitable for industrialized production; and in-vivo / in-vitro tests prove that the prepared loropetalum chinense total polyphenol extract with mass percentage of total polyphenol of more than or equal to 50 percent has good functions of resisting inflammation, relieving heat, easing pain, resisting bacteria, and the like, and can be applied to the preparation of a drug for treating burn, sunburn and trauma. The loropetalum chinense total polyphenol can be prepared into soft plaster, gel, troche, capsule, soft capsule, oral liquid, syrup, drop pill, injection, and other preparations.

Description

technical field [0001] The invention relates to a medicine for treating burns and scalds, in particular to a preparation method of total polyphenols of loropetalum for treating burns, sunburns and traumas. Background technique [0002] Burn, sunburn, trauma are a kind of commonly encountered diseases, often take place in daily life, and the burn incidence rate such as fire, gas explosion burn and water, oil scald is very high, is about 2%. Sunburn is a disease that is often overlooked but seriously affects human health. In mild cases, it can cause redness, swelling, and peeling, and in severe cases, it can cause skin cancer, especially for workers, farmers, and soldiers who work outdoors for a long time. Ultraviolet burns and sunburns The incidence rate is higher. With the deterioration of the environment, the greenhouse effect, the intensity of ultraviolet rays is getting higher and higher, and sunburn has attracted more and more attention. So far, there are no anti-sunbu...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P17/02A61K127/00
Inventor 吴振邱鹰昆游璐茜赵虎义赵玉芬
Owner XIAMEN UNIV
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