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Degradable Mg-Zn-Zr alloy endovascular stent and comprehensive processing technique thereof

A treatment process and comprehensive treatment technology, applied in metal material coating process, stent, medical science and other directions, can solve problems such as reducing the degradation rate, and achieve the effect of good degradation rate

Inactive Publication Date: 2012-08-29
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Based on the current research status at home and abroad, the method of using hydrofluoric acid treatment to improve the corrosion resistance of Mg-Zn-Zr alloy and its vascular stents and reduce the degradation rate has not been reported yet.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: Taking the φ60mmMg-3wt%Zn-0.8wt%Zr of self-smelting as raw material through

[0022] (1) Homogenization treatment process: temperature 400°C, time 24h;

[0023] (2) Hot extrusion process: the extrusion ratio is 60;

[0024] (3) Processing vascular stents;

[0025] (4) Aging treatment process: 170 ℃, time is 20h;

[0026] (5) Surface treatment process: the concentration of hydrofluoric acid is 10%, the treatment temperature is 20° C., and the treatment time is 24 hours.

[0027] The vascular stent processed by the above process has excellent apparent quality, no cracks on the stent wall, the thickness of the hydrofluoric acid treatment layer is about 0.3-0.5 μm, and it is well combined with the matrix, and the surface layer does not fall off or crack after the balloon is propped up.

Embodiment 2

[0028] Embodiment 2: Take the φ60mmMg-3wt%Zn-0.8wt%Zr of voluntary smelting as raw material through

[0029] (1) Homogenization treatment process: temperature 400°C, time 24h;

[0030] (2) Hot extrusion process: the extrusion ratio is 60;

[0031] (3) Processing vascular stents;

[0032] (4) Aging treatment process: 170 ℃, time is 20h;

[0033] (5) Surface treatment process: the concentration of hydrofluoric acid is 25%, the treatment temperature is 20° C., and the treatment time is 24 hours.

[0034] The vascular stent processed by the above process has excellent apparent quality, no cracks on the stent wall, the thickness of the hydrofluoric acid treatment layer is about 0.5-0.7 μm, and it is well combined with the matrix, and the surface layer does not fall off or crack after the balloon is propped up.

Embodiment 3

[0035] Embodiment 3: take the φ60mmMg-3wt%Zn-0.8wt%Zr of self-smelting as raw material through

[0036] (1) Homogenization treatment process: temperature 400°C, time 24h;

[0037] (2) Hot extrusion process: the extrusion ratio is 60;

[0038] (3) Processing vascular stents;

[0039] (4) Aging treatment process: 170 ℃, time is 20h;

[0040] (5) Surface treatment process: the concentration of hydrofluoric acid is 40%, the treatment temperature is 20°C, and the treatment time is 24h.

[0041] The vascular stent processed by the above process has excellent apparent quality, no cracks on the stent wall, the thickness of the hydrofluoric acid treatment layer is about 0.8-1 μm, and it is well combined with the matrix, and the surface layer does not fall off or crack after the balloon is propped up.

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Abstract

The invention relates to technology for processing and treating endovascular stent materials, in particular to heat treatment and surface hydrofluoric acid treatment technology for biodegradable Mg-Zn-Zr alloy endovascular stents, wherein the homogenizing temperature is between 400 and 450 DEG C, and the homogenizing time is between 20 and 24 hours; the hot extrusion ratio is between 40 and 60; the forming temperature of capillary tubes is between 150 and 200 DEG C, and flower patterns of the tube wall are engraved by laser; the temperature of time effect treatment technology is between 150 and 200 DEG C, and the time is between 18 and 24 hours; and the surface treatment technology comprises that: the concentration of hydrofluoric acid is between 10 and 40 percent, the treatment temperature is between 20 and 60 DEG C, and the treatment time is between 12 and 24 hours. The comprehensive treatment technology not only can guarantee to process the alloys into clinically required endovascular stents but also can guarantee that the endovascular stents have reasonable degradation rate and good biocompatibility in a biological in vivo blood environment, particularly can guarantee the corrosion rate of thickness regulation and control alloys of surface MF2 layers after hydrofluoric acid treatment, makes the degradation rate of the stents be between 0.1 and 0.2 mm / yr, and meets the requirement on the mechanical supporting time of the endovascular stents in treatment.

Description

【Technical field】 [0001] The invention relates to a treatment process for intravascular stent materials, in particular to a heat treatment and surface hydrofluoric acid treatment process for a biodegradable Mg-Zn-Zr alloy intravascular stent. 【Background technique】 [0002] Since the stent is implanted in the blood vessel, it mainly provides mechanical support for the blood vessel during the specific period of injury healing. Therefore, the ideal intravascular stent should give sufficient mechanical support to the lesion stage and be gradually absorbed by the organism after healing. The traditional cardiovascular stents currently used are generally made of stainless steel or polymer materials. The stainless steel stent permanently exists in the blood vessel, and the foreign body triggers a local inflammatory response, which has a long-term stimulating effect on the surrounding tissue and increases the possibility of restenosis of the blood vessel. The mechanical properties ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04C22F1/16C23C22/34A61F2/82
Inventor 陈民芳王晓伟由臣王振武
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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