Acarbose chewing tablets

A technology of acarbose and tablet cores, applied in the field of medicine, can solve problems such as hardening, affecting taste and efficacy, and easy moisture absorption of acarbose

Inactive Publication Date: 2009-07-29
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to its special physical properties, acarbose is easy to absorb moisture and hardens after absorbing moisture, seriously affecting the taste and efficacy, which makes many high-quality and cheap excipients unusable

Method used

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  • Acarbose chewing tablets

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1 powder coating

[0030] Prescription: (1000 tablets / grain)

[0031] Acarbose 100g

[0032] Opadry AMB 20g

[0033] Xylitol 200g

[0034] Process: add Opadry AMB to 95% ethanol and stir to prepare a coating solution with a concentration of 5-15%, which is used as a coating solution for later use.

[0035] Put the acarbose into the fluidized bed and adopt the top spraying process. Preheat the fluidized bed temperature to 40°C. Spray the above coating solution at a rate of 3.5-5g per minute, the air flow rate is 8-15Hz, and the spray compressed air pressure is 1bar. The coating process depends on controlling the inlet air temperature to maintain the product temperature At 30°C-40°C. After the coating solution is sprayed, the product temperature is maintained at 40°C and dried for 30-60 minutes, and the weight gain is controlled at 5-40%.

[0036] After coating, the powder is evenly mixed with xylitol, and compressed into tablets, chewable tablets or fill...

Embodiment 2

[0037] Embodiment 2 particle coating

[0038] Prescription: (1000 tablets / grain)

[0039] Acarbose 100g

[0040] Acrylic resin E100 10g

[0041] Hydrogenated Vegetable Oil 20g

[0042] Xylitol 200g

[0043] Glyceryl Behenate 3g

[0044] Process: add acrylic resin E100 into 95% ethanol and stir until dissolved, add hydrogenated vegetable oil into hot isopropanol and stir until dissolved, mix the two to form a coating solution with a concentration of 5-15%, and use it as a coating solution for later use.

[0045] Acarbose and xylitol are mixed and added with 95% ethanol solution to make soft material, granulated through 30 mesh, dried, and granulated through 20 mesh. The granules are placed in a fluidized bed, using a top spray process. Preheat fluidized bed temperature to 40 DEG C. Spray with the speed of per minute 3.5-5g with the coating liquid in embodiment 1, air velocity is 8-15Hz, spray compressed air pressure is 1bar. Coating process is by controlling inlet air tem...

Embodiment 3

[0047] Embodiment 3 tablet coating

[0048] Tablet core prescription: (1000 tablets)

[0049] Acarbose 100g

[0050] Microcrystalline Cellulose 193g

[0051] Aspartame 3g

[0052] Magnesium Stearate 2g

[0053] Silica 2g

[0054] Coating prescription: (1000 tablets)

[0055] Opadry A MB 10g

[0056] 95% ethanol 100g

[0057] Process: add Opadry AMB to 95% ethanol and stir to prepare a coating solution with a concentration of 5-15%, which is used as a coating solution for later use.

[0058] Acarbose, microcrystalline cellulose and aspartame are mixed and added with 95% ethanol solution to make soft material, granulated through 30 mesh, dried, and granulated through 20 mesh. Magnesium stearate and silicon dioxide are added, mixed and compressed into tablets.

[0059] The tablet core is put into a coating pot, coated with the above coating solution, aged in the pot at 50°C for 10-40 minutes after coating, and the weight gain of the coating is controlled at 1-5%. Detailed...

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PUM

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Abstract

The invention relates to an acarbose moistureproof preparation and a method for preparing the same. The disclosed acarbose moistureproof preparation consists of acarbose, a medical auxiliary material and a moistureproof coating layer. Powders, particles or the medical auxiliary material are used to prepare a tablet core; and the tablet core is coated with a moistureproof coating material to form the acarbose, wherein the moistureproof coating material can be dissolved in stomach. The acarbose has the disadvantages of easily absorbing moisture and hardening so that the auxiliary materials with low price and high quality cannot be used. The method adopts coating technology, does not influence the disintegration property of the tablet core, greatly improves stability of a product in a humid environment, solves the problem of moisture absorption and increases selectivity of the auxiliary material.

Description

technical field [0001] The invention relates to an oral preparation with acarbose as an active ingredient, belonging to the technical field of medicine. Background technique [0002] The incidence of diabetes is still increasing year by year. China has become the hardest-hit area, and the number of diabetic patients ranks second in the world after India. According to the data provided by the World Health Organization (WHO), the prevalence of diabetes in developed countries has reached as high as 5% to 10%, and in my country it is about 3%. According to the most conservative calculation, the number of diabetic patients in China increases by one million every year. There are 2,700 new cases; by 2030, the number of diabetic patients in the world will double compared with 2000. [0003] Analysts pointed out that for some time to come, the incidence of type 1 diabetes will remain relatively stable, but the number of patients with type 2 diabetes will increase steadily. Type 2 d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K9/36A61K31/7034A61P3/10
Inventor 潘福生叶杉王琼
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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