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Cefixime sustained-release tablets and preparation method thereof

A technology of cefixime and sustained-release materials, which is applied in the direction of pharmaceutical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the difficulty of industrialization and the cumbersome preparation process of cefixime sustained-release tablets And other issues

Inactive Publication Date: 2009-08-05
SHANDONG BESTCOMM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of cefixime sustained-release tablets disclosed in US20040005361 and CN101084904 is relatively cumbersome, and industrialization is difficult

Method used

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  • Cefixime sustained-release tablets and preparation method thereof
  • Cefixime sustained-release tablets and preparation method thereof
  • Cefixime sustained-release tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: cefixime, HPMC-K100M CR, lactose, and microcrystalline cellulose are passed through a 40-mesh sieve, and sodium lauryl sulfate and micropowder silica gel are passed through a 80-mesh sieve. Take the prescribed amount of cefixime and sodium lauryl sulfate and mix evenly, add the prescribed amount of lactose, microcrystalline cellulose, HPMC-K100M CR and mix thoroughly, then add the prescribed amount of micropowder silica gel, mix evenly, and press into tablets.

Embodiment 2

[0029]

[0030] Preparation method: replace HPMC-K100M CR in Example 1 with HPMC-K4M CR and HPMC-K15M CR, and the rest are the same as Example 1.

Embodiment 3

[0032]

[0033] Preparation method: take cefixime, HPMC K4M CR, microcrystalline cellulose, and lactose and pass through a 40-mesh sieve, and poloxamer, sodium lauryl sulfate, and micropowdered silica gel pass through a 80-mesh sieve. Weigh the prescribed amount of cefixime, sodium lauryl sulfate, and poloxamer and mix evenly, then add the prescribed amount of HPMC-K4M CR, microcrystalline cellulose, and lactose, mix thoroughly, and then add the prescribed amount of micropowder silica gel to mix Uniformly, pressed into tablets, that is to say.

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PUM

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Abstract

The invention relates to a slow-release tablet prepared from cefixime and pharmaceutically acceptable auxiliary materials. The slow-release tablet is characterized in that: the slow-release tablet consists of the following raw materials and auxiliary materials in portion by weight: 200 portions of cefixime(counted as an anhydride), 20 to 200 portions of at least one pharmaceutically acceptable slow-release material which can control the drug to continuously and completely release, 20 and 400 portions of a pharmaceutically acceptable excipient and 5 to 100 portions of at least one solubilizer which can effectively improve the release rate of the drug. The slow-release tablet is easy to prepare and facilitates the industrialized production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations. More specifically, the present invention relates to a sustained-release monolayer tablet of cefixime and a preparation method thereof. Background technique [0002] The chemical name of Cefixime is (6R, 7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-(carboxymethoxyimino)acetamide]-8 -Oxy-3-ethylene-5-thio-1-azabicyclo[4,2,0]octa-2-ene-2-carboxylic acid trihydrate. It is a white to light yellow crystalline powder, odorless or slightly special smell, easily soluble in methanol, slightly soluble in ethanol and water, insoluble in chloroform and ether. [0003] Cefixime is the third generation of oral cephalosporin antibiotics. It exerts antibacterial activity by inhibiting the synthesis of bacterial cell walls. It has the advantages of broad spectrum, high efficiency, wide distribution in the body, strong tissue penetration, and stability to β-lactamase. It is suitable for infections caused by St...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K47/32A61K47/36A61K47/38A61K31/546A61P31/04
Inventor 李斌安芳贤
Owner SHANDONG BESTCOMM PHARMA CO LTD
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