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Polymerization method of polyvinyl pyrrolidone

A technology of polyvinylpyrrolidone and polymerization method, which is applied in the field of polymerization of polymer materials, can solve problems such as yellow color of polymerization liquid, restriction of sales range, and non-conformity of quality, so as to improve yield, meet domestic demand, and have large production capacity Effect

Inactive Publication Date: 2009-08-19
BOAI NKY PHARMA LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main defect of this process is that there are jelly cross-linked products in the produced polyvinylpyrrolidone polymer solution, which leads to yellow color of the polymer solution, poor taste, and low yield, which cannot meet the needs of domestic pharmaceutical, cosmetics and other industries for this product. , the quality does not meet the requirements of American USP31 version and European EP6.0 version, which not only greatly restricts the domestic sales scope of this product, but also affects the sales in European and American markets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1. Select 200 parts of solvent water, 100 parts of NVP raw materials and 10 parts of initiator dibenzoyl peroxide by weight;

[0017] 2. Put 200 parts of solvent water into the polymerization kettle at one time, when the temperature in the kettle reaches 95°C, start the mixer, first put 30 parts of NVP raw materials, 3 parts of initiator dibenzoyl peroxide into the polymerization kettle, and react for 5 hours Finally, the remaining 70 parts of NVP raw materials and 7 parts of initiator dibenzoyl peroxide were put into the polymerization kettle, and the inner temperature of the kettle was controlled at 95° C. After 5 hours of reaction, this batch of polymerization reactions ended.

Embodiment 2

[0019] 1. Select 200 parts of solvent water, 100 parts of NVP raw materials and 5 parts of initiator dibenzoyl peroxide by weight;

[0020] 2. Put 200 parts of solvent water into the polymerization kettle at one time. When the temperature in the kettle reaches 80°C, start the mixer, and put the NVP raw material and initiator into the polymerization kettle in three times according to the proportion. The temperature of the kettle is controlled at 80°C for reaction. Put in 20 parts of NVP raw materials and 0.8 parts of initiator for the first time, react for 1.5 hours; put in 35 parts of NVP raw materials and 1.2 parts of initiator for the second time, react for 1.5 hours; put in 45 parts of NVP raw materials and 3 parts of initiator for the third time Agent, after 6 hours of reaction, this batch of polymerization ends.

Embodiment 3

[0022] 1. Select 200 parts of solvent water, 100 parts of NVP raw materials and 8 parts of initiator tert-butyl perzincate by weight;

[0023] 2. Put 200 parts of solvent water into the polymerization kettle at one time. When the temperature in the kettle reaches 50°C, start the mixer, put the NVP raw material and initiator into the polymerization kettle in four times in proportion, and control the temperature of the kettle at 50°C for reaction. Put in 20 parts of NVP raw materials and 1 part of initiator for the first time, and react for 1 hour; put in 23 parts of NVP raw materials and 1 part of initiator for the second time, and react for 1.5 hours; agent, reacted for 2 hours; for the fourth time, 29 parts of NVP raw materials and 4 parts of initiator were added, and the batch of polymerization ended after 3 hours of reaction.

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Abstract

A polymerization process of polyvinylpyrrolidone comprises the following steps: (1) selecting 200 parts of a solvent, 100 parts of a NVP raw material and 5-10 parts of an initiator by weight; and (2) adding the solvent once into a polymerization kettle, starting an agitator, proportionally adding the NVP raw material and the initiator to the polymerization kettle for a plurality of times, and controlling reaction temperature at 50-95 DEG C and total reaction time at 7-10h. Polymer products produced by the process (comprising PVPK-12, PVPK-25, PVPK-30, PVPK-60 and PVPK-90) eliminate presence of jellylike crosslinkers, have clear color and no odor and improved yield (higher than 10%) without large-scale investment, and fully utilize the existing equipment in industrial production.

Description

technical field [0001] The invention belongs to the field of polymerization of polymer materials, and in particular relates to a polymerization method for eliminating jelly cross-linked products in polyvinylpyrrolidone polymerization liquid. Background technique [0002] Polyvinylpyrrolidone (including PVPK-12, PVPK-25, PVPK-30, PVPK-60, PVPK-90 and copolymers of N-vinylpyrrolidone and vinyl acetate, cross-linked polymer PVPP) is used in the fields of medicine and health care , can be used as high-efficiency binders, suspension stabilizers, thickeners, drug delay agents, slow-release agents; in the field of cosmetics industry, it is mainly used in hair and skin care products, and can be used as film-forming agents, thickeners, Lubricants and adhesives; in the field of food hygiene, it can be used as a stabilizer and clarifying agent for beer, fruit juice, drinking wine, and vinegar, which can increase its transparency, improve its color and taste. [0003] The polyvinylpyrr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F126/10
Inventor 王坚强
Owner BOAI NKY PHARMA LTD
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