Compound of Lansoprazole and a preparation method thereof

Abstract

The invention relates to a compound of Lansoprazole and a preparation method thereof, belonging to the technical field of medicines. The refined product of Lansoprazole with purity being not less than 99.8% can be obtained, thus reaching the requirement of injection level, fundamentally solving the problem of no raw medicines for the injection at present and guaranteeing the product quality of the Lansoprazole for injection. The method is simple in operation and suitable for the industrial production.

Description

technical field [0001] The invention relates to a refining method of a lansoprazole compound, which belongs to the technical field of medicine. Background technique [0002] Lansoprazole, chemical name: 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-sulfinyl]-1H -benzimidazole, molecular formula: C 16 h 14 f 3 N 3 o 2 S, molecular weight: 369.36, structural formula: [0003] [0004] It is a new type of drug that inhibits gastric acid secretion, it acts on the H of gastric parietal cells + -K + -ATPase, which makes parietal cell H + It cannot be transported to the stomach, so that the amount of gastric acid in the gastric juice is greatly reduced. It is clinically used for duodenal ulcer, gastric ulcer, reflux esophagitis, Zollinger-Ellison syndrome (gastrinoma) ) treatment, the curative effect is remarkable, and it has inhibitory effect on Helicobacter pylori. [0005] Lansoprazole is almost insoluble in water, and it was first listed in the form of...

AI Technical Summary

Problems solved by technology

This method just simply dissolves lansoprazole, absorbs, refines, and can not fundamentally solve the low problem of lansoprazole raw material purity, and the refined product purity that obtains does not obtain corresponding improvement

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