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Anti-tumoral, antibacterial and antiviral pharmaceutical composition (variants)

一种抗肿瘤、抗病毒的技术，应用在生产医学和兽医用途药品的制药,具有综合抗肿瘤,药物组合物,抗菌和抗病毒活性的物质领域，能够解决有病机体免疫系统保护功能下降、抗肿瘤活性不够高、毒副作用等问题

Inactive Publication Date: 2012-07-04
尼克雷亚历山德罗维奇巴杜林
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]The agents indicated above are more advanced antitumor agents due to the use of silver salts as cytostatic agents, but this prototype composition has the obvious disadvantage of insufficient antitumor activity High due to limitations of silver nitrate toxicity which negatively affects living organisms
In addition, the composition does not solve the problem of complex therapy, including antibacterial action on the body
Moreover, malignant tumors and leukocyte hyperplasia are often (in most cases) accompanied by bacterial infection, which is due to the decline in the protective function of the immune system of the diseased organism, including the toxic side effects of the above-mentioned chemical agents
Also, currently antipyrine is no longer produced due to the availability of more potent components

Method used

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  • Anti-tumoral, antibacterial and antiviral pharmaceutical composition (variants)
  • Anti-tumoral, antibacterial and antiviral pharmaceutical composition (variants)
  • Anti-tumoral, antibacterial and antiviral pharmaceutical composition (variants)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Mix 0.016 g of silver nitrate with 0.03 g of hexamethylenetetramine and 0.02 g of sodium thiosulfate, add 0.07 g of α-aspartic acid and 0.07 g of niacin, and dissolve them all in the required amount of in the water. The solution showed some turbidity and the resulting composition was studied for antitumor, antibacterial and antiviral activity.

Embodiment 2

[0037] Mix 1 g of silver nitrate, 0.8 g of hexamethylenetetramine and 3 g of sodium thiosulfate, add 0.4 g of niacin and 0.4 g of alpha-aspartic acid or asparagine, both dissolved in the required amount of water, to obtain solutions to study its antitumor, antibacterial and antiviral activities.

Embodiment 3

[0039] 1.6 g of silver nitrate was mixed with 1.4 g of hexamethylenetetramine and 5 g of sodium thiosulfate, and 0.7 g of α-asparagine and 0.7 g of niacin were added, all dissolved in the required amount of water. Part of the reagents became precipitated, and the resulting composition was studied for antitumor, antibacterial, and antiviral activities.

[0040] embedded trace 3 H-thymidine has carried out the antitumor activity of inhibiting cell growth to tumor cells according to the second scheme of the pharmaceutical composition of the present invention (comprising the platinum compound component containing imidazole) through 24 hours of latent (pulse per minute) For comparison, radioactivity measurements were performed on a β-counter Mark-III. The evaluation of the cell growth inhibitory activity of the pharmaceutical composition of the present invention is in the presence of 10% calf embryo serum (2 * 10 5 cells / ml) of human (K-562 and HUT-102 lines) erythrocytic tissue ...

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Abstract

The inventive pharmaceutical compositions relate to medicine and veterinary sciences, in particular to agents which exhibit a combined anti-tumoral, antibacterial and antiviral activity and can be used for producing medicinal and veterinary formulations. In the first variant, the composition contains in mass%: 0.016-1.6 silver nitrate, 0.07-0.7 alpha-asparaginic acid, 0.07-0.7 nicotinic acid, 0.03-1.4 hexamethylenetetramine, 0.02-5.0 sodium thiosulphate, the rest being water. In the second variant, the composition contains in mass%: 0.016-1.6 silver nitrate, 0.03-1.4 hexamethylenetetramine orimidazol, 0.056-5.6 cis-[Pt(NH3)2Im2]Cl2 or cis-[Pt(NH2OH)2Im2]Cl2, 0.07-0.7 alpha-asparagic acid or asparagin, 0.07-0.7 nicotinic acid, the rest being water. The pharmaceutical compositions exhibit the anti-tumoral activity, which is greater than that of the known agent, and simultaneously perform antibacterial and antiviral action on an organism.

Description

technical field [0001] The pharmaceutical composition proposed by the present invention (its various versions) relates to the fields of medicine and veterinary medicine, in particular to substances with comprehensive antitumor, antibacterial and antiviral activities, which can be used in the pharmacy for the production of medicines for medical and veterinary use. Background technique [0002] Known a kind of antineoplastic, antibacterial drug composition, it has included silver compound, wherein has hexamethylenetetramine silver nitrate and tetraiodo-hexamethylenetetramine (Russian patent 2181050, the 7th edition of international patent classification M∏K7A61K33 / 18, A61K33 / 38, 2002). However, this pharmaceutical composition is known to be highly toxic and, moreover, not well soluble in water, so it cannot be used for the preparation of intravenous injections for internal medicine. [0003] Also known is a platinum metal-based antitumor drug composition (Russian patent 207...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/38A61K31/195A61K31/455A61K31/132A61K33/04A61K31/282A61P35/00A61P31/04A61P31/12A61K9/08A61K33/243
CPCA61K9/0019A61K33/38A61K31/455A61K31/132A61K33/24A61K31/282A61K31/195A61K45/06A61P31/00A61P31/04A61P31/12A61P35/00A61K33/243A61K2300/00
Inventor 伏拉迪米尔·米哈伊洛维奇·普洛特尼科夫
Owner 尼克雷亚历山德罗维奇巴杜林