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Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins

A virus genome and carrier technology, applied in the direction of virus antigen components, resistance to vector-borne diseases, etc., can solve the problems of low vaccine production, insufficient production capacity to meet the needs of pandemics, and biosafety issues, so as to increase the quality of antigens, Effects that eliminate the chance of adverse reactions and are easy to exchange

Inactive Publication Date: 2009-09-09
SANOFI PASTEUR BIOLOGICS CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] 3. Low yield of vaccine
[0020] 5. Production capacity is insufficient to meet the needs of the pandemic
[0021] 6. Biosafety issues in large-scale production of inactivated antigenic viruses
However, these methods require potent adjuvants to enhance the immunogenicity of these weak immunogens

Method used

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  • Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins
  • Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins
  • Construction of recombinant virus vaccines by direct transposon-mediated insertion of foreign immunologic determinants into vector virus proteins

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Embodiment Construction

[0071] The present invention provides methods of producing viral vectors comprising heterologous peptides, viral vectors comprising these peptides, methods of delivering these peptides by administering the live vector, e.g. Compositions. Details of these viral vectors, peptides, methods and compositions are provided below.

[0072] A central feature of the present invention involves the construction of live recombinant vaccines by randomly inserting immunogenic peptides of various pathogenic organisms into the proteins of live attenuated vaccine viruses for efficient expression of these peptides in infected cells and presentation to the immune system, The goal is to induce potent, long-lasting immunity to the target pathogen. For efficient presentation, foreign peptides representing, for example, B-cell epitopes are randomly inserted into viral proteins, such as those secreted only by infected cells (e.g., NS1 and the amino-terminal portion of flavivirus prM) or virus particl...

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Abstract

The invention provides viral vectors, such as chimeric flavivirus vectors, including foreign peptides inserted into the target proteins of the vectors, methods of making and using these vectors, and compositions including the vectors.

Description

field of invention [0001] The invention relates to the construction of a recombinant virus vaccine and the corresponding composition and method through direct transposon-mediated insertion of exogenous immune determinant into carrier virus protein. Background of the invention [0002] Vaccination is one of the greatest achievements in medicine, saving millions from the effects of devastating disease. Before vaccines became widely available, tens of thousands of children and adults died each year from infectious diseases in the United States alone, and many more worldwide. Vaccinations are widely used to prevent and treat infections caused by bacteria, viruses and other pathogens. Several different methods are used in vaccination including the administration of killed pathogens, live attenuated pathogens and inactive pathogen subunits. In viral infections, live vaccines have been found to elicit the most potent and sustained protective immune responses. [0003] Live atten...

Claims

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Application Information

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IPC IPC(8): A61K39/12
CPCY02A50/30
Inventor K·V·普加乔夫A·A·鲁缅采夫
Owner SANOFI PASTEUR BIOLOGICS CO
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