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Albendazole oxide hydrochloride premix for animals

A technology of oxyalbendazole hydrochloride and premix, which is applied in the field of preparation and application of feed pharmaceutical additives, and can solve problems such as huge workload and the like

Inactive Publication Date: 2009-09-23
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nowadays, the scale of large-scale farms often reaches more than 10,000 heads. If tablets, suspensions, injections and other dosage forms are used to prevent and treat parasitic diseases, the workload will be huge

Method used

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  • Albendazole oxide hydrochloride premix for animals
  • Albendazole oxide hydrochloride premix for animals
  • Albendazole oxide hydrochloride premix for animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Preparation of 1% oxyalbendazole hydrochloride premix

[0025] Commercial oxyalbendazole hydrochloride (98% content, purchased from Sichuan Huashu Animal Pharmaceutical Co., Ltd.) and zeolite powder were pulverized and passed through a No. 4 standard drug sieve and dried in an oven at 105°C for 2 hours to make the water content less than 1 %. Accurately weigh 1.02kg of oxyalbendazole hydrochloride and 98.98kg of zeolite powder, first pour half of the zeolite powder into a commonly used mixer (the same below), dilute oxyalbendazole hydrochloride with an equal amount of zeolite powder and then Pour it into the mixer, then add the remaining zeolite powder, and mix it for 10 minutes, which is the finished product.

Embodiment 2

[0027] Preparation of 2% oxyalbendazole hydrochloride premix

[0028] Oxyalbendazole hydrochloride (content is 98%, purchased from Sichuan Huashu Animal Pharmaceutical Co., Ltd.) and zeolite powder are pulverized and passed through No. 4 standard drug sieve, and dried in an oven at 105°C for 2h to make the water content less than 1 %. Accurately weigh 2.04kg of oxyalbendazole hydrochloride (content 98%) and 97.96kg of zeolite powder, first pour half of the zeolite powder into the mixer by weight, and then pour oxyalbendazole hydrochloride into an equal amount of zeolite powder after dilution Put it into the mixer, and then add the remaining zeolite powder, timed and mixed for 10 minutes, which is the finished product.

Embodiment 3

[0030] Preparation of 5% oxyalbendazole hydrochloride premix

[0031] Oxyalbendazole hydrochloride (content is 98%, purchased from Sichuan Huashu Animal Pharmaceutical Co., Ltd.) and zeolite powder are pulverized and passed through No. 4 standard drug sieve, and dried in an oven at 105°C for 2h to make the water content less than 1 %. Accurately weigh 5.10kg of oxyalbendazole hydrochloride (content 98%) and 94.90kg of zeolite powder, first pour half of the zeolite powder into the mixer by weight, and then pour oxyalbendazole hydrochloride into the mixer after diluting it with an equal amount of zeolite powder Put it into the mixer, and then add the remaining zeolite powder, timed and mixed for 10 minutes, which is the finished product.

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PUM

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Abstract

The invention belongs to the application technical field of medical feed additives, more particularly relates to preparation and application of an albendazole oxide hydrochloride premix for animals. In the premix, the albendazole oxide hydrochloride is taken as an active ingredient which is evenly mixed with a carrier zeolite powder to obtain the premix. The premix consists of the following parts of materials by weight: 1-20 parts of the albendazole oxide hydrochloride with less than 1% of water and 80-90 parts of the zeolite powder with less than 1% of water which are mixed to obtain a finished product by a conventional method. The premix prepared by the invention can be added to a compound feed for pigs, sheep and cattle for preventing parasitic diseases in animals. Administration dose is 5-10mg per kilogram of body weight based on the active ingredient. The premix prepared by the invention has the advantages of good performance, high bioavailability and quick residue elimination.

Description

technical field [0001] The invention relates to the technical field of preparation and application of feed drug additives, in particular to the preparation and application of a veterinary anti-endoparasite premix. Background technique [0002] Oxyalbendazole hydrochloride is a new benzimidazole antiparasitic drug under research in my country, which is the hydrochloride form of oxyalbendazole. Oxyalbendazole can combine with tubulin to inhibit the absorption function of worms and cause the death of worms. It can also inhibit the fumarate reductase system and hinder the generation of adenosine triphosphate. , Fasciola hepatica have good curative effect. [0003] Albendazole has poor water solubility (the solubility in water at 25°C is only 0.2 μg / ml), resulting in low bioavailability. JECFA reports that the bioavailability of albendazole in pigs is about 35%, and in cattle The bioavailability in the body is about 50%, and the low bioavailability affects the systemic anthelmi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/4184A61K47/02A61P33/00
Inventor 袁宗辉韩勇黄玲利王玉莲陈冬梅戴梦红陶燕飞彭大鹏王旭刘振利
Owner HUAZHONG AGRI UNIV
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