Hypertension-ameliorating agent
A high blood pressure, improving agent technology, applied in cardiovascular system diseases, drug combination, food preparation and other directions, can solve problems such as unknown effect of improving hypertension
Inactive Publication Date: 2009-10-07
KYOWA HAKKO BIO CO LTD +1
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- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
[0005] However, the hypertension-improving effect of PQQ or its esters, or their salts is not yet known.
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0074] According to the compounding ratio recorded in Table 3, soft drink water (10 bottles) for improving high blood pressure was produced.
[0075] 【table 3】
[0076]
[0077] Dilute to 1000mL with water.
Embodiment 2
[0079] According to the ratio recorded in Table 4, 1000 mL of tea beverage for improving high blood pressure was prepared.
[0080] 【Table 4】
[0081]
[0082] Elution was performed with 1000 mL of water.
Embodiment 3
[0084] According to the compounding ratio described in Table 5, chewing gum (30 pieces) for improving high blood pressure was manufactured.
[0085] 【table 5】
[0086]
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The objective of the present invention is to provide a safe and highly effective hypertension-ameliorating agent. The present invention provides a hypertension-ameliorating agent, comprising a compound represented by general formula (I) (wherein R1, R2, and R3 are the same as or different from each other, and each represents lower alkyl, lower alkenyl, lower alkynyl, aralkyl, araryl, phenyl, or a hydrogen atom) or a salt thereof as an active ingredient.
Description
technical field [0001] The present invention relates to a hypertension improving agent containing pyrroloquinoline quinone or its ester or its salt as an active ingredient. Background technique [0002] High blood pressure is a risk factor for myocardial infarction, angina pectoris, cerebral infarction, cerebral hemorrhage, and cerebrovascular dementia. Keeping blood pressure in the normal range is crucial to maintaining health. Antihypertensive drugs include: diuretics that lower blood pressure by causing sodium and water diuresis and reducing circulating blood volume; sympathetic depression that lowers blood pressure by centrally or peripherally suppressing the activity of the sympathetic nervous system that plays an important role in blood pressure regulation A calcium antagonist that inhibits the uptake of calcium into vascular smooth muscle cells to dilate blood vessels; angiotensin I that inhibits the production of the pressor substance angiotensin II while increasing ...
Claims
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IPC IPC(8): C07D471/04A23K1/16A61K31/437A61P9/12A23L1/30A61K31/4738A61K31/4745
CPCA23V2002/00A61K31/437C07D471/04A23K1/1628A23L1/30A23K20/137A23L33/10A61P9/12A23V2200/326
Inventor 荻野史子神谷俊一中野昌彦吉川和俊
Owner KYOWA HAKKO BIO CO LTD