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Application of 5' nucleotide in preparation of medicines and health-care foods for improving weakened immune function

A technology for health food and immune function, which can be used in the preparation of medicines for improving immune function, health food, 5' nucleotide products and new uses thereof, and can solve the problems of 5' nucleotide immune dysfunction and other problems.

Inactive Publication Date: 2009-10-21
珍奥集团股份有限公司
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 5' Nucleotide is a high-purity 5'AMP: 5'CMP: 5'GMPNa produced by using ribonucleic acid as raw material by bio-enzyme technology 2 : 5'UMPNa 2 Mixture, there is no report on the role of 5' nucleotides in improving immune function and its application in medicine and health food

Method used

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  • Application of 5' nucleotide in preparation of medicines and health-care foods for improving weakened immune function
  • Application of 5' nucleotide in preparation of medicines and health-care foods for improving weakened immune function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0010] Example: 5' Nucleotide Improves Experimental Research of Immunofunction

[0011] 1. Materials and methods

[0012] 1. Sample: 5' nucleotide (5'AMP: 5'CMP: 5'GMPNa 2 : 5'UMPNa 2 =22.8∶26.6∶30.2∶20.4), production process: heat denaturation of ribonucleic acid (RNA) with a purity of 90% → enzymatic hydrolysis with nuclease P1 → ultrafiltration → adsorption on anion resin → stepwise elution → nanofiltration desalination → Thin film concentration → carbon powder decolorization → crystallization → drying.

[0013] 1.2 Experimental animals: 180 clean-grade female Balb / c mice, aged 6-8 weeks, weighing 18-22 grams, provided by the Experimental Animal Center of Peking University Health Science Center, with the approval number SCXK11-00-0004, kept in a clean-grade animal room. The temperature of the breeding environment is 25° C., and the humidity is 60% RH.

[0014] 1.3 Test indicators: mouse spleen and thymus weight; antibody-forming cells (IgM-PFC / spleen) were measured by J...

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PUM

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Abstract

The invention relates to an application of 5' nucleotide in preparation of medicines and health-care foods for improving weakened immune function. The nucleotide is 5' nucleotide mixture which takes ribonucleic acid (RNA) as raw material, produced by enzymic degradation, has the purity of more than 99%, and is prepared by mixing 5' AMP, 5' CMP, 5' GMPNa2 and 5' UMPNa2 according to the mixture ratio of 22.8:26.6:30.2:20.4. The 5'nucleotide can remarkably enhance mouse ConA induced lymphopoiesis capacity, increases the quantity of hemolysis plaque, improves the spleen NK cell percentage and has obvious effect on improving weakened immune function since feed is short of the nucleotide.

Description

technical field [0001] The invention relates to a 5' nucleotide product and its new application, specifically the use of ribonucleic acid as a raw material to produce 5' nucleotides through enzymatic degradation in the preparation of drugs and health food for improving immune function. It belongs to the field of medicine and food health care. Background technique [0002] In recent years, low immune function, including primary and secondary immune function deficiency, deficiency or damage, has been widely concerned by medical scientists at home and abroad, because of themselves and the various complications induced, especially infection, Often make the patient's condition serious, difficult to treat, and can cause serious consequences, even life-threatening. If it is economical and practical to improve the immune function of the body through the development of health food, it will bring great prospects to my country's health care industry. [0003] Nucleic acid is a substa...

Claims

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Application Information

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IPC IPC(8): A61K31/708A61K31/7076A61K31/7072A61K31/7068A61P37/02A23L1/30C12P19/30A23L33/10A23L33/13
Inventor 李恕李勇董锋
Owner 珍奥集团股份有限公司
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