Manufacturing technique of amantadine hydrochloride and special equipment thereof

Abstract

The invention relates to a manufacturing technique of amantadine hydrochloride, which comprises: after being processed by decarburization and filtered, amantadine hydrochloride water solution is added into a tank to be concentrated; after the material in the tank is added with water and cooled, the remained water in the material is pressed out by a filter board; acetone is added into the tank to stand still for soaking the material; the tank is pressurized, and the acetone is pressed out by compressed air; a jacket enters a steam rotary tank and is dried; and the amantadine hydrochloride in the tank is discharged out. Special equipment of the amantadine hydrochloride comprise: a stirring motor arranged on the tank, an agitating vane arranged inside the tank, and a shaft coupling connected with the upper end of the agitating vane; wherein, axle mechanical seal is adopted between the agitating vane and the tank; the upper part of the tank is provided with a man-hole opening, a viewing mirror hole, a temperature measuring hole, a stirring hole and a feeding hole; the lower end of the tank is provided with a sintering filter board, and silica gel ring seal is adopted between the tank and the filter board as well as a cover board. The technique leads the whole process flow of reaction, concentration or crystallization, washing, filtering and drying to be completed in a device in a sealing way, thus improving the safety of production and avoiding the pollution of materials.

Description

Technical field [0001] The invention relates to a production process and equipment for the chemical and pharmaceutical industries to react, concentrate or crystallize, wash, filter and dry dry powder materials, especially acidic materials, in particular to a production process for amantadine hydrochloride and its special equipment. Background technique [0002] At present, the pharmaceutical industry generally uses traditional production processes to produce amantadine hydrochloride. The traditional process and equipment of amantadine hydrochloride are as follows: 1. Press filter the amantadine hydrochloride aqueous solution after decarburization and filtration into an enamel kettle, stir and distill under reduced pressure for concentration. After concentration, put the amantadine hydrochloride material into In the barrel; 2. After the barrel is placed in the water tank for 4 hours to cool, the material is added to the three-foot centrifuge to spin dry and dehydrated; 3. The dehy...

AI Technical Summary

Problems solved by technology

The existing problems are: 1. It is difficult to discharge the material after concentration in the enamel kettle, and only wooden sticks or PTFE barrels can be used, which is difficult to operate; 2. Too much equipment is used in the entire refining production process, and the medicine is exposed in the space It takes a long...

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