Detection method of chromosome synteny homology region and system thereof

A homologous region and homologous technology, applied in the field of genetic engineering, can solve the problems of low detection efficiency and high complexity, and achieve the effects of low complexity, avoiding influence and high sensitivity

Inactive Publication Date: 2009-10-21
SHENZHEN HUADA GENE INST +1
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Problems solved by technology

[0005] The purpose of the present invention is to provide a detection method for chromosome synteny and homology regions, aiming to solve the existing problems of high complexity and low detection efficiency when visually detecting chromosome synteny and homology regions

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  • Detection method of chromosome synteny homology region and system thereof
  • Detection method of chromosome synteny homology region and system thereof
  • Detection method of chromosome synteny homology region and system thereof

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[0025] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0026] In the embodiment of the present invention, the reference genes in the reference gene set are located on the target genome to obtain gene copy loci, and then the overlapping gene copies on the target genome are clustered together to form fuzzy loci representing gene loci, and finally according to The obtained fuzzy sites represent gene loci, and the syntenic and homologous regions of chromosomes are automatically detected by using the dynamic programming fuzzy site positioning algorithm.

[0027] figure 1 It shows the implementation process of the detection method for chromosome synteny an...

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Abstract

The invention is applicable to the gene engineering field, and provides a detection method of a chromosome synteny homology region and a system thereof. The method comprises the following steps: positioning all reference genes in a reference genome to a target genome to form a gene copy seat; copying and clustering lapped genes according to the gene copy seat to form a fuzzy site gene representative seat; and detecting the synteny homology region of the chromosome by a dynamic planning fuzzy site locating algorithm according to the fuzzy site representative gene seat. The detection method of the chromosome synteny homology region provided by the embodiment of the invention can help detect the chromosome synteny homology region automatically with high sensitivity and low complexity, and avoids influence of objective factors on detection of chromosome synteny homology region in visual examination.

Description

technical field [0001] The invention belongs to the field of genetic engineering, in particular to a detection method and system for chromosome synteny and homology regions. Background technique [0002] Gene duplication refers to the duplication of one or more copies of a DNA segment in the genome. This DNA segment can be a small segment of the genome sequence, an entire chromosome, or even the entire genome. Gene duplication is one of the most important driving forces of genome evolution and one of the main reasons for the generation of genes with new functions and the evolution of new species. [0003] Gene duplication is widespread, and it is estimated that a whole genome duplication occurred in the yeast genome 100 million years ago. Whole gene duplication is very rare in vertebrates, but very common in plants. Many plants have undergone whole genome duplication at the ancestral stage or recently, such as the ancestral genome duplication event in dicots and the recent...

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Application Information

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IPC IPC(8): G06F19/00C12Q1/68G06F19/18
Inventor 李俊白寅琪李瑞强王俊杨焕明汪建
Owner SHENZHEN HUADA GENE INST
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