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Application of N-alkanoyl cordycepin in preparing drugs for treating tumor diseases

A technology of alkanoyl cordycepin and tumors, which is applied in the direction of anti-tumor drugs, drug combinations, pharmaceutical formulations, etc. It can solve the problems of low practical value and achieve good application prospects and strong anti-tumor activity

Inactive Publication Date: 2009-11-11
SOUTHWEST UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At the same time, people are still working on the structural modification of cordycepin to slow down its metabolic rate in the body. Two kinds of cordycepin derivatives have been reported in the past, one is the phosphorylated polymer of cordycepin, and the other is 3'-nitrocordycepin However, the metabolic rate of these two derivatives in the body is still relatively fast, and the practical value is not high

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  • Application of N-alkanoyl cordycepin in preparing drugs for treating tumor diseases
  • Application of N-alkanoyl cordycepin in preparing drugs for treating tumor diseases

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Embodiment Construction

[0012] In order to make the purpose, technical solution and advantages of the present invention clearer, the antitumor activity of N-alkanoyl cordycepin is described in detail below through experimental examples.

[0013] Experimental method: (1) Reagent preparation: trypsin solution with a concentration of 0.25% (w / v): dissolve 1 g of trypsin in 100 mL of water, filter and sterilize, and dilute with 4×D-Hanks solution to the desired concentration before use. required concentration, and with a concentration of 5.6% (w / w) NaHCO 3 Adjust the pH to 7.2; tetramile salt (MTT) solution with a concentration of 5 mg / mL: dissolve 250 mg of MTT in 50 mL of PBS with a concentration of 0.01 mol / L and a pH of 7.4, filter and sterilize, and store at 4°C in the dark;

[0014] (2) Preparation of cell culture medium: RPMI-1640 medium dry powder 10.4g, NaHCO 3 Dissolve 2.0g, sodium pyruvate 110.0mg, L-glutamine 293.0mg, glucose 3.8g, penicillin 200,000 units, streptomycin 200,000 units and ph...

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Abstract

The invention discloses an application of N-alkanoyl cordycepin in preparing drugs for treating tumor diseases. An in vitro study result shows that, compared with cordycepin, the N-alkanoyl cordycepin has stronger antineoplastic activity, and can be prepared into highly-effective and safe antineoplastic drugs, is used for treating the tumor diseases such as leukaemia, liver cancer, bladder cancer and breast cancer and the like, and has good application prospect.

Description

technical field [0001] The invention relates to a new application of the compound, in particular to the application of N-alkanoyl cordycepin in the preparation of drugs for treating tumor diseases. Background technique [0002] Since Cunningham et al. isolated cordycepin (Cordycepin) from the culture liquid of Cordyceps militaris (L.) Link in 1951, its various biological activities have gradually been recognized by people, and it has become one of the research hotspots in the world in recent years. . [0003] Cordycepin is an adenosine analog, because it can interfere with the synthesis of cellular DNA and RNA, inhibit the post-transcriptional modification of hnRNA and mRNA, inhibit the activation of adenylate cyclase, and can promote cell differentiation and rebuild the cytoskeleton, It enhances the chemotaxis of macrophages, inhibits the synthesis of specific proteins, and can also inhibit the activities of polyadenylate polymerase and protein kinase, thereby showing stro...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P35/00A61P35/02
Inventor 叶小利李学刚
Owner SOUTHWEST UNIVERSITY
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