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Application of paederoside acid or plant extract containing same

The technology of gallic acid and plant extract is applied in the application field of preparing anti-influenza A virus medicine, and the effect of obvious curative effect and low price is achieved.

Inactive Publication Date: 2010-02-03
SHANGHAI INST OF PHARMA IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0018] Taking a comprehensive view of the reports at home and abroad, there is no evidence that chicken sagenic acid and the total iridoid glycosides extract containing it have anti-influenza virus efficacy.

Method used

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  • Application of paederoside acid or plant extract containing same
  • Application of paederoside acid or plant extract containing same
  • Application of paederoside acid or plant extract containing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1 Extraction of chicken sagitta total iridoid glycosides extract and chicken saragynic acid

[0033] 1) Extraction of total iridoid glycosides and separation of chicken yaragylic acid:

[0034] References: Quang, D.N., T. Hashimoto, et al. (2002). Iridoid glucosides fromroots of Vietnamese Paederia scandens. Phytochemistry 60(5): 505-514.

[0035] Take 1 kg of the Chinese herbal medicine Ji Yateng, extract with 8 kg of 75% ethanol under reflux for 2 hours, concentrate to dryness, dissolve in 10% ethanol solution, extract with n-butanol, concentrate to dryness to obtain the effective part product, and the effective part product yield is 2.7 %, wherein the total iridoid glycoside content exceeds 70%. The total iridoid glycosides were subjected to repeated silica gel column chromatography (400 mesh, 30 times the effective fraction mass, chloroform:methanol=30:1~1:1 gradient elution) and reversed-phase silica gel column chromatography (400 mesh, 50 times Effective...

Embodiment 2

[0038] Embodiment 2 in vitro anti-influenza virus test

[0039] The in vitro anti-influenza A virus test was carried out in accordance with the influenza virus cell method stipulated in the "Guidelines for Preclinical Research of New Drugs (Western Medicine)" (1993) formulated by the Pharmaceutical Administration of the Ministry of Health.

[0040] 1) Materials:

[0041] Chicken Yateng total iridoid glycosides extract and chicken sarigerinic acid are all prepared by the method of Example 1;

[0042] Cell model: dog kidney cells MDCK cells, provided by the Institute of Bioengineering, Chinese Academy of Medical Sciences;

[0043] Virus strain: Influenza virus (A3 / Jingke / 30 / 95), provided by Shanghai Center for Disease Control and Prevention;

[0044] Ribavirin: Guangdong Zhaoqing Xinghu Pharmaceutical Factory.

[0045] 2) Test process

[0046] References: Xu Shuyun, Bian Rulian, Chen Xiu. "Pharmacological Experimental Methodology", People's Health Publishing House, 2005 (3 edi...

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Abstract

The invention discloses application of paederoside acid shown as a formula 1 or a plant extract containing the same in medicaments in preparing anti-influenza A virus. The compound and the plant extract containing the same have the obvious anti-influenza A virus activity, and have obvious effects of treating influenza A or influenza A viral pneumonia.

Description

technical field [0001] The present invention relates to the application of chicken seramic acid or the plant extract containing it, in particular to the application of chicken seramic acid or the plant extract containing it in the preparation of anti-influenza A virus medicine. Background technique [0002] Influenza (influenza), referred to as influenza, is an acute respiratory infectious disease caused by influenza virus. There are three types of influenza virus, A, B, and C. Because type A is prone to mutation, the influenza epidemic caused by it spreads quickly, spreads widely, and has a great impact. It is especially threatening to the elderly, weak, sick, and infants, and often leads to complications. And die. At present, influenza is a key surveillance disease in China, and it is listed as a Class C infectious disease in my country's "Law on the Prevention and Control of Infectious Diseases" for management. [0003] Currently available anti-influenza drugs are: [...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61K36/74A61P11/00A61P31/12
Inventor 王曙光庄昌龙李波高雯孔德云
Owner SHANGHAI INST OF PHARMA IND CO LTD
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