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Quinolinone alkaloid derivant as well as preparation method and application thereof

A technology of alkaloid derivatives and quinolinones is applied in the application field of microbial pesticides and insecticides, which can solve problems such as insecticides that have not yet been seen, and achieve the effect of broad application prospects.

Active Publication Date: 2010-02-10
OCEAN UNIV OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, no medicinal value microbial pesticide insecticides have been obtained from marine fungi.

Method used

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  • Quinolinone alkaloid derivant as well as preparation method and application thereof
  • Quinolinone alkaloid derivant as well as preparation method and application thereof
  • Quinolinone alkaloid derivant as well as preparation method and application thereof

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Embodiment Construction

[0009] In preparing the compounds of the present invention, the following steps are taken:

[0010] (1) Carry out strain culture to marine fungus (Penicillium sp.ZZF32#) in strain culture medium earlier, the culture medium used contains glucose 1.0% (percentage by weight, the same below), yeast extract 0.1%, peptone 0.2%, Agar 1.0%, sodium chloride 0.3%, the rest is water. When used, it was made into a test tube slant, and the above-mentioned fungal strains were cultured at 30° C. for 5 days.

[0011] The strain medium contains 0.1%-5.0% of glucose, 0.01%-1% of yeast extract, 0.01%-1% of peptone, 0.1%-3.0% of agar, 0.05%-5% of sodium chloride and the rest is water. The culture temperature is 15-35° C., and the culture time is 3-10 days.

[0012] (2) The fungal strain obtained from the above culture is fermented and cultured, and the used fermentation medium contains 1.0% of glucose, 0.1% of yeast extract, 0.2% of peptone, 0.3% of sodium chloride, and the rest is water. The ...

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Abstract

The invention relates to a quinolinone alkaloid derivant as well as a preparation method and the application thereof. The preparation method comprises the following steps: firstly, carrying out strain culture for marine fungi in a strain culture medium; then carrying out fermentation culture in a fermentation culture medium; filtering obtained fermentation liquor to obtain thallus; extracting theobtained thallus by an organic solvent; carrying out chromatographic separation for an extracting solution after the extracting solution is concentrated; and concentrating obtained eluent to obtain yellow powder, i.e. the quinolinone alkaloid derivant. The compound has very high killing effect on cotton aphids, diamond back moths and heliothis virescens, can be used as pesticide of microorganismsand also has large-scale production of raw materials and wide application prospect.

Description

technical field [0001] The present invention relates to a quinolinone alkaloid derivative 2-pyrrolyl-3-carboxy-4-quinolinone extracted and separated from the thalline of marine endophytic fungi and a preparation method thereof and as a microbial pesticide application. Background technique [0002] Since penicillin was prepared from fungi in 1929, fungal metabolites have become a rich source of drugs, and the vast majority of clinically used antibiotics are derived from fungi and bacteria. The metabolites of fungi also have other medicinal value, such as anti-tumor, treatment of cardiovascular diseases, enzyme inhibitors, etc. Due to the particularity of the marine environment and the functions of microorganisms in the ecosystem, marine microorganisms have developed unique metabolic methods, and also provide metabolites that terrestrial microorganisms cannot provide. People are looking for new special drugs and microbial pesticides from marine microorganisms Great hopes. H...

Claims

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Application Information

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IPC IPC(8): C07D401/04C12P17/16A01N43/42A01P7/04C12R1/80
Inventor 邵长伦林永成王长云周世宁顾玉诚佘志刚
Owner OCEAN UNIV OF CHINA
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