Micronomicin sulfate eye drop and preparation method thereof
A technology of noromycin and eye drops, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low cure rate and poor therapeutic effect, etc. To achieve the effect of high cure rate, low toxicity and side effects, and simple process
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Example Embodiment
[0043] Example 1
[0044] The eye drops of this embodiment contain:
[0045] Micronomycin sulfate 3,000,000 units,
[0046] 8.0 grams of sodium chloride,
[0047] Sodium metabisulfite 2.0 grams,
[0048] 5.5 grams of hydroxypropyl cellulose with a concentration of 0.75% by weight,
[0049] 1000ml water for injection.
[0050] The preparation method is as follows: add 5.5 grams of hydroxypropyl cellulose aqueous solution with a concentration of 0.75% by weight to a container containing 400 ml of water for injection, stir and mix well, then add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite After fully stirring and dissolving, add 3,000,000 units of micropromycin sulfate. After dissolving and dissolving, adjust the pH to 7.0 with 0.5mol sodium hydroxide solution, add 600ml water for injection to 1000ml water for injection, use 0.22um micropore Sterilize the filter membrane.
Example Embodiment
[0051] Example 2
[0052] The eye drops of this embodiment contain:
[0053] Micronomycin sulfate 3,000,000 units,
[0054] 8.0 grams of sodium chloride,
[0055] Sodium metabisulfite 2.0 g
[0056] 1000ml water for injection.
[0057] The preparation method is as follows: add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite into a 400ml water for injection container, fully stir to dissolve, add 3,000,000 units of micromycin sulfate, fully stir to dissolve, use 0.5mol Adjust pH to 7.0 with aqueous sodium hydroxide solution, add 600ml water for injection to 1000ml water for injection, sterilize with 0.22μm microporous membrane.
Example Embodiment
[0058] Example 3
[0059] The process and equipment of this embodiment are basically the same as in embodiment 1, except that the aqueous solution containing 2,000,000 units of micronomycin sulfate, 5.3 grams of sodium chloride, 1.3 grams of sodium metabisulfite, and a concentration of 0.03% by weight of hydroxypropyl cellulose 8 grams, 600 milliliters of water for injection.
[0060] The preparation method is as follows: adding 8 grams of an aqueous solution of hydroxypropyl cellulose with a concentration of 0.03% by weight to 240 milliliters of water for injection, and adding the above amounts of sodium chloride, sodium metabisulfite and micronomycin sulfate, Adjust the pH to 6.0 with 0.3 mol sodium hydroxide aqueous solution, add 360 ml of water for injection, and sterilize with a 0.22 μm microporous membrane.
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