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Micronomicin sulfate eye drop and preparation method thereof

A technology of noromycin and eye drops, which can be applied to pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of low cure rate and poor therapeutic effect, etc. To achieve the effect of high cure rate, low toxicity and side effects, and simple process

Active Publication Date: 2010-02-17
LIAONING QIANLIMING PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commercially available chloramphenicol eye drops have a certain therapeutic effect on bacterial conjunctivitis, but the therapeutic effect is not very good and the cure rate is low

Method used

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  • Micronomicin sulfate eye drop and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The eye drops of the present embodiment contain:

[0045] Micronomycin sulfate 3,000,000 units,

[0046] Sodium chloride 8.0 grams,

[0047] Sodium metabisulfite 2.0 g,

[0048] Concentration is the hydroxypropyl cellulose 5.5 grams of 0.75% weight percentage concentration,

[0049] Water for injection 1000ml.

[0050] Its preparation method is: add 5.5 grams of hydroxypropyl cellulose aqueous solution with a concentration of 0.75% by weight into a container filled with 400 ml of water for injection, stir and mix evenly, then add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite , after fully stirring and dissolving, add 3,000,000 units of micronomycin sulfate, divide and stir to dissolve, adjust the pH to 7.0 with 0.5mol sodium hydroxide solution, add 600ml of water for injection to 1000ml of water for injection, and use 0.22um microporous Membrane sterilization.

Embodiment 2

[0052] The eye drops of the present embodiment contain:

[0053] Micronomycin sulfate 3,000,000 units,

[0054] Sodium chloride 8.0 grams,

[0055] Sodium metabisulfite 2.0 g

[0056] Water for injection 1000ml.

[0057] Its preparation method is: add 8.0 grams of sodium chloride and 2.0 grams of sodium metabisulfite into a container containing 400 ml of water for injection, stir and dissolve fully, add 3,000,000 units of micronomycin sulfate, stir and dissolve, and use 0.5mol of Adjust the pH to 7.0 with sodium hydroxide aqueous solution, add 600ml of water for injection to 1000ml of water for injection, and sterilize with a 0.22 μm microporous membrane.

Embodiment 3

[0059]The process and equipment of this embodiment are basically the same as those of Example 1, except that the aqueous solution of hydroxypropylcellulose containing 2,000,000 units of micronomycin sulfate, 5.3 grams of sodium chloride, 1.3 grams of sodium metabisulfite, and a concentration of 0.03% by weight 8 grams, 600 ml of water for injection.

[0060] Its preparation method is: the aqueous solution 8 grams of the hydroxypropyl cellulose of concentration 0.03% by weight is added in the water for injection that fills 240 milliliters, after adding the above-mentioned amount of sodium chloride, sodium metabisulfite and micronomycin sulfate, Adjust the pH to 6.0 with 0.3 mol of sodium hydroxide aqueous solution, add 360 ml of water for injection, and sterilize with a 0.22 μm microporous membrane.

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Abstract

The invention relates to a micronomicin sulfate eye drop with micronomicin sulfate as a main component. The micronomicin sulfate eye drop can be used for curing eye diseases including bacterial conjunctivitis and the like, and contains micronomicin sulfate, sodium chloride, sodium metabisulfite and water for injection. The micronomicin sulfate eye drop also contains hydroxy propyl cellulose for achieving better curative effect. A preparation method comprises the following steps: adding the components into the water for injection, fully stirring and dissolving, adjusting a pH value to 6.8-7.2 through 0.3-0.5mol of sodium hydroxide aqueous solution, then adding a needed amount of water for injection, and filtering and sterilizing through a 0.22-micron microporous filtering film. The eye drophas a high curative ratio for the eye diseases, small side effects, simple process and equipment of the preparation method and little investment.

Description

1. Technical field [0001] The present invention relates to an eye drop for treating eye diseases and a preparation method thereof, more specifically a micronomicin sulfate eye drop (Micronnomicin Sulfate Eye Drops) with micronomicin sulfate as the main component [0002] ) and its preparation method. 2. Background technology [0003] Bacterial conjunctivitis is still a common and frequently-occurring disease in ophthalmology, especially in rural areas, it is more common in spring and summer. For example, "pink eye disease" is prevalent and there are many patients. Commercially available chloramphenicol eye drops have a certain therapeutic effect on bacterial conjunctivitis, but the therapeutic effect is not very good, and the cure rate is low. 3. Contents of the invention [0004] The object of the present invention is to research a kind of eye drop that has higher cure rate to bacterial conjunctivitis and other external eye infection eye diseases and research its prepar...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7036A61K47/02A61K47/38A61P27/02A61P31/02
Inventor 林继华
Owner LIAONING QIANLIMING PHARMA GROUP
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