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Saussurea involucrate nano particles and preparation method and application thereof

A nanoparticle, snow lotus technology, applied in pharmaceutical formulations, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of difficult scale promotion, single mode of administration, inconvenience to carry, etc., and achieve encapsulation efficiency and sustained release. Good effect, stable release rate, high drug loading effect

Inactive Publication Date: 2010-05-05
SINOPHARM GRP XINJIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there are very few snow lotus products at present, and the whole herb is used as medicine by the folks, and the active ingredients are mainly obtained by boiling and soaking in wine. The active ingredient is used as medicine, and its absorption efficiency cannot be guaranteed
[0006] The Snow Lotus Injection that appeared in recent years has better solved the problem of the utilization of active ingredients and the benefit of human body absorption, but because the application of its preparation requires certain conditions and is inconvenient to carry, it has affected its wide application.

Method used

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  • Saussurea involucrate nano particles and preparation method and application thereof
  • Saussurea involucrate nano particles and preparation method and application thereof
  • Saussurea involucrate nano particles and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Weigh 60mg Saussurea oleifera Injection and dissolve it in 100mL ethylene glycol with a frequency of 20000Hz ultrasonic, as the inner water phase, weigh 5g PLGA and add it to the beaker, add 1:3 dichloromethane-acetone 3000g, as the oil phase, add Span -80 250g, Tween-80 500g, add a stir bar to the oil phase, stir at a high speed of 3000rpm on a magnetic stirrer to mix the oil phase and emulsifier evenly, then slowly add 300mL of the inner water phase to the oil phase, Stir at 1500rpm to form W / O colostrum with blue opalescence. Weigh 600g of Tween-80, add 100000mL of distilled water as the external water phase, drop the prepared W / O colostrum into it under the action of emulsifier, and stir at 1500rpm to prepare W / O / W double emulsion nano solution , rotating the prepared nano-solution on a rotary evaporator to remove the organic solvent to obtain the snow lotus nano-particles of the present invention.

[0034] The PLGA materials used in this and subsequent examples we...

Embodiment 2

[0053] Weigh 100mg of Snow Lotus Injection intermediate and ultrasonically dissolve it in 100mL of ethylene glycol and ethanol in a ratio of 1:1 as the inner water phase with a frequency of 100000Hz, weigh 15g of PLGA and add it to a beaker, and add 1:1.5 dichloromethane -Acetone to a weight of 1500g, as the oil phase, add Span-80 100g, Tween-80 350g each, add a stir bar to the oil phase, stir at a high speed of 5000rpm on a magnetic stirrer to make the oil phase and the emulsifier mix evenly, Take 140mL of the internal water phase and slowly add it dropwise to the oil phase, and stir at 1500rpm to form W / O colostrum with blue opalescence. Weigh 350g of Tween-80, add 55000mL of distilled water as the external water phase, drop the prepared W / O colostrum into it under the action of emulsifier, stir at 1500rpm to obtain W / O / W double emulsion nano solution, The prepared nano-solution is rotary-evaporated on a rotary evaporator to remove the organic solvent to obtain the snow lotu...

Embodiment 3

[0055] Weigh 800mg of Saussurea sauraceae water extract and ultrasonically dissolve it in 100mL of 1,2-propanediol at a frequency of 50000Hz to form the inner water phase, weigh 35mg of PLGA and add it to a beaker, add 2:1 dichloromethane-acetone to a weight of 3500g as the oil phase , add Span-80 500g, Tween-80 750g, add a stir bar to the oil phase, stir at a high speed of 4000rpm on a magnetic stirrer to mix the oil phase and emulsifier evenly, take 600mL of the water phase and slowly add it to the oil phase Phase, 2000rpm stirring to form W / O colostrum with blue opalescence. Weigh 650g of Tween-80, add 9000mL distilled water as the external water phase, drop the prepared W / O colostrum into it under the action of emulsifier, and stir at 2000rpm to prepare W / O / W double emulsion nano solution , rotating the prepared nano-solution on a rotary evaporator to remove the organic solvent to obtain the snow lotus nano-particles of the present invention.

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Abstract

The invention discloses saussurea involucrate nano particles and a preparation method and an application of the prepared saussurea involucrate nano particles. The saussurea involucrate nano particles in the invention is prepared by the following steps: taking oil phase W emulsified particles as the carrier, taking the aqueous solution of the effective component in the saussurea involucrate or the alcohol solvent O as the internal aqueous phase carrying on the oil phase W emulsified particles by stirring at a high speed to form W / O particles, and coating a covering layer of emulsifier outside the W / O particles to form W / O / W multiple emulsion nano particles. Measurements and tests prove that the grain diameter of the saussurea involucrate nano particles in the invention is in a range of 60-800 nm, the average grain diameter is 134.6nm; saussurea involucrate nano particles in the invention have a shape of quasisphere, smooth surface, even size, no bond between particles, high drug-loading rate, good encapsulating rate and releasing effect and stable releasing rate, can be prepared into oral liquid, tablets, various capsules such as soft capsules, hard capsules and microcapsules, and can be prepared into parenteral solution, lotion, embrocation, patch or electuary.

Description

Technical field: [0001] The invention relates to a snow lotus nano particle, a preparation method and application thereof. Background technique: [0002] Saussurea is a plant of the genus Asteraceae in the family Asteraceae. It is a precious Chinese herbal medicine in my country and has rich medicinal value. The chemical components of snow lotus mainly include: flavonoids, sugars, alkaloids, terpenes and their derivatives. The main pharmacological effects are anti-inflammatory and analgesic, antispasmodic, antihypertensive and antiasthmatic, and enhancing the body's immunity. [0003] Snow lotus medicinal materials belong to the genus Compositae, and are used as the whole herb or aboveground parts of various plants as crude drugs. They are commonly used ethnic and folk medicines in Tibet, Xinjiang, Qinghai, Gansu, Yunnan, Sichuan and other plateau frigid regions. Among them, Tianshan Snow Lotus mainly grows above the snow line of Tianshan Mountain and Kunlun Mountain in Xi...

Claims

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Application Information

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IPC IPC(8): A61K36/287A61K9/14A61P9/12A61P11/06A61P29/00A61P37/04
Inventor 贾晓光波拉提·马卡比力沈琦王歆君朱国强刘家国赵心怡
Owner SINOPHARM GRP XINJIANG PHARMA
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