Cyclodextrin inclusion compound of 3,5-dyhydroxyl-4-isopropyl toluylene and preparation method thereof
A technology of isopropyl stilbene and cyclodextrin inclusion complex, applied in the field of chemistry, can solve the problems of low water solubility, low dissolution rate, poor drug stability, etc., and achieves improved stability, bioavailability, solubility and stability. The effect of increased dissolution and high production efficiency
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Embodiment 1-9
[0026] Example 1-9 Preparation of cyclodextrin inclusion compound of 3,5-dihydroxy-4-isopropylstilbene by grinding method
[0027] The raw material ratio of each embodiment is shown in the table below:
[0028]
[0029] Its preparation method is carried out according to the following step sequence:
[0030] (11) Take clathrate material and deionized water with a weight ratio of 1:1.5-5, mix them in a mortar and grind for 8-12 minutes to obtain solution A1;
[0031] (12) Take the drug 3,5-dihydroxy-4-isopropyl stilbene and alcohol solvent in a weight ratio of 1:2, mix and dissolve to obtain solution B1;
[0032] (13) Solution B1 is gradually added dropwise to solution A1. After continuing to grind, put it in the refrigerator for 24--26 hours, filter it with suction, wash it, dry it and grind it into a uniform powder to obtain 3,5-dihydroxy-4 - Cyclodextrin inclusion complex of isopropylstilbene.
[0033] Below take embodiment 2 as example to illustrate the specific operat...
Embodiment 10-18
[0037] Example 10-18 Preparation of cyclodextrin inclusion compound of 3,5-dihydroxy-4-isopropylstilbene by ultrasonic method
[0038] The raw material ratio of each embodiment is shown in the table below:
[0039]
[0040] Its preparation method is an ultrasonic method, and is carried out according to the following sequence of steps:
[0041] (21) Take clathrate material and deionized water with a weight ratio of 1:12.5--25, heat ultrasonically, mix evenly and dissolve to obtain solution A2;
[0042] (22) Take the drug 3,5-dihydroxy-4-isopropyl stilbene and alcohols inclusion solvent with a weight ratio of 1:2, mix and dissolve to obtain solution B2; gradually drop solution B2 during the ultrasonic process Add it to the solution A2 kept at 10-60°C, continue to sonicate until the total ultrasonic time is 5-35min, put it in the refrigerator for 24-26h, filter with suction, wash and dry to get 3,5-dihydroxy-4-isopropyl Cyclodextrin inclusion complexes of stilbenes.
[0043...
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