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Compound traditional Chinese medicine extract composition for preventing and treating diabetes

A composition and diabetes technology, applied in the direction of drug combination, pharmaceutical formula, metabolic diseases, etc., can solve the problems of unclear active components, unclear mechanism of action, simple and rough process, etc., to adjust blood lipid disorders and prevent and treat diabetes , the effect of increased intake

Active Publication Date: 2010-06-23
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in clinical application, the raw material drug is decocted with water to make a decoction, the process is simple and rough, the dosage is large, and the active components are not clear, and the mechanism of action is not clear

Method used

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  • Compound traditional Chinese medicine extract composition for preventing and treating diabetes
  • Compound traditional Chinese medicine extract composition for preventing and treating diabetes
  • Compound traditional Chinese medicine extract composition for preventing and treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Mix the two medicinal materials of astragalus and licorice in a ratio of 6:1, add water to decoct twice, the amount of water added each time is 10 times the amount of the medicinal materials, and the decoction time is 2 hours. Each extract was filtered, and the combined filtrates were concentrated under reduced pressure to a concentration of 1 g of crude drug per 1 ml. Ethanol was added to the concentrated solution to make the alcohol content in the medicinal solution 55%, and allowed to stand for 12 hours. The precipitate was washed with 95% ethanol, dried in vacuum, and crushed into extract powder to obtain component A. After recovering the solvent from the supernatant, add an appropriate amount of water, extract 3 times with an equal volume of diethyl ether, then extract 5 times with an equal volume of n-butanol, combine the n-butanol extracts, recover the solvent under reduced pressure, vacuum dry, and pulverize Ointment powder, get component B. Component A and com...

Embodiment 2

[0025] Mix the two medicinal materials of astragalus and licorice in a ratio of 6:1, add water to decoct twice, the amount of water added each time is 12 times the amount of the medicinal materials, and the decoction time is 2 hours. Each extract was filtered, and the combined filtrates were concentrated under reduced pressure to a concentration of 0.8 g of crude drug per 1 ml. Ethanol was added to the concentrated solution to make the alcohol content in the medicinal solution 75%, and allowed to stand for 12 hours. The precipitate was washed with 95% ethanol, dried in vacuum, and crushed into extract powder to obtain component A. After recovering the solvent from the supernatant, add an appropriate amount of water, put it on a D101 macroporous adsorption resin column, elute with water, 30% ethanol, and 70% ethanol in sequence, collect the 70% ethanol eluted part, recover the solvent under reduced pressure, and vacuum dry , and crushed into extract powder to obtain component B...

Embodiment 3

[0027] Mix astragalus and licorice at a ratio of 6:1, add water to decoct twice, each time adding water is 12 times the amount of the medicinal materials, and decoct for 1.5 hours. The medicinal solution is filtered, the combined filtrates are concentrated under reduced pressure to a concentration of 1.2 g of crude drug per 1 ml, the concentrated solution is added with ethanol to make the medicinal solution contain 65% alcohol, and allowed to stand for 12 hours. The precipitate was washed with 95% ethanol, dried in vacuum, and crushed into extract powder to obtain component A. After recovering the solvent from the supernatant, add an appropriate amount of water, put it on the AB-8 macroporous adsorption resin column, and elute with water, 20% ethanol, and 60% ethanol in sequence, collect the 60% ethanol precipitated part, recover the solvent under reduced pressure, and vacuum Dried and crushed into extract powder to obtain component B. Component A and component B are uniforml...

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Abstract

The invention discloses a compound traditional Chinese medicine extract composition for preventing and treating diabetes, comprising a component A and a component B with the weight ratio of 1:1 which are obtained from herbal medicines of astragalus and glycyrrhiza through water decoction, ethanol precipitation, organic solvent extraction or macroporous adsorption resin separation based on an ancient traditional Chinese medicine formula of Astragalus Liuyi Soup. Proved by invitro cell glucose consumption experiments, the composition can promote the glucose consumption of HePG2 cells; proved by animal in vivo experiments, the composition has remarkable function of reducing blood glucose of a hyperglycemic rat caused by alloxan, can increase the uptake of glucose in liver cells to promote glycogen synthesis, adjusts the disorder state of blood fat and improves the pathological changes of pancreas and liver tissues.

Description

technical field [0001] The invention relates to a traditional Chinese medicine compound extract composition for preventing and treating diabetes. Background technique [0002] Diabetes is a common endocrine and metabolic disease that seriously endangers human health worldwide. Diabetes not only has a high incidence rate, but also causes chronic complications of multiple systems and organs in the heart, brain, kidney, eyes, peripheral blood vessels, nerves, etc., which are the main reasons for the disability and mortality of diabetes. Therefore, Diabetes has become the third largest killer after malignant tumors and cardiovascular diseases. Efforts to explore and actively find ideal methods and drugs for the treatment and control of diabetes have become one of the key issues to be solved and overcome in today's world medicine. The treatment of diabetes with traditional Chinese medicine starts from the overall adjustment, based on syndrome differentiation and treatment, emph...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P3/10
Inventor 师彦平陈娟
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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