Water-soluble salvia miltiorrhiza extractive, preparation and application thereof

A water-soluble extract and extract technology, applied in the field of Salvia miltiorrhiza extract, Chinese medicine extract, its preparation and use, can solve the problems of unstable clinical efficacy, inconsistent with the modernization and internationalization of traditional Chinese medicine, and frequent occurrence of adverse reactions.

Active Publication Date: 2010-06-23
TIANJIN TASLY ZHIJIAO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Danshen injection is a commonly used drug for the clinical treatment of coronary heart disease, angina pectoris, myocardial infarction, ischemic stroke, etc. However, the existing preparations are not clear about the active ingredients and the quality control indicators are not strict, which leads to unstable clinical efficacy and frequent adverse reactions. Occurs and does not meet the requirements of modernization and internationalization of traditional Chinese medicine

Method used

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  • Water-soluble salvia miltiorrhiza extractive, preparation and application thereof
  • Water-soluble salvia miltiorrhiza extractive, preparation and application thereof
  • Water-soluble salvia miltiorrhiza extractive, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0297] Danshen decoction pieces 1000 grams, 6000ml water reflux extraction four times, 0.5 hours each time. Combine the extracts, centrifuge, and pass the supernatant through 500 grams of polyamide, rinse with 12,000 ml of water, and elute with 12,000 ml of absolute ethanol. gram of macroporous resin, washed with 4000ml of water, eluted with 8000ml of 50% ethanol, concentrated ethanol eluate, and dried under reduced pressure. Obtain 30 grams of extracts, the content of Danshen water-soluble extract B is 58.3%, rosmarinic acid 3.5%, shikonic acid 4.2%, Danshen water-soluble extract E 0.5%, and the total content of the four components is 66.5%. Total phenolic acids 85%.

Embodiment 2

[0299] Danshen decoction pieces 1000 grams, 5000ml 75% ethanol reflux extraction three times, 1 hour each time. Combine the extracts, concentrate to no alcohol, filter, adjust the pH value of the filtrate to 3.5, and pass through 300 grams of polyamide, wash with 12000 ml of water, elute with 12000 ml of 50% ethanol, concentrate the eluate to no alcohol and add water to about 1 gram of medicinal materials / ml , the concentrated solution was adjusted to pH 5.0, passed through 1000 grams of macroporous resin, washed with 4000 ml of water, eluted with 1000 ml of 50% ethanol, concentrated ethanol eluate, and dried under reduced pressure. Obtain 45 grams of extracts, the content of Salvia miltiorrhiza water-soluble extract B is 71%, rosmarinic acid 3.1%, shikonic acid 2.7%, Danshen water-soluble extract E 0.2%, and the total content of the four components is 77%. Total phenolic acids 92%.

Embodiment 3

[0301] Salvia miltiorrhiza decoction pieces 1000 grams, 5500ml water reflux extraction three times, the first time for 1 hour, the second and third time for 0.5 hours. Combine the extracts, adjust the pH value to 2.5, centrifuge, the supernatant is passed through 500 grams of polyamide, washed with 12000 ml of water, eluted with 12000 ml of 0.1% sodium bicarbonate, the eluent is adjusted to pH 2.0, the concentrated solution is passed through 1000 grams of macroporous resin, 4000 ml Rinse with water, elute with 8000ml of 50% ethanol, concentrate the ethanol eluate, and dry under reduced pressure. Obtain 30 grams of extract, the content of water-soluble extract B of Danshen root is 55.48%, 3.55% of rosmarinic acid, 4.42% of shikonic acid, 0.32% of water-soluble extract of Danshen root, and the total content of four components is 63.77%. Total phenolic acids 87%.

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Abstract

The invention provides a water-soluble salvia miltiorrhiza extractive, wherein the weight percent of total phenolic acid is 80-100 percent. The water-soluble salvia miltiorrhiza extractive is characterized by comprising the following components in percent by weight: 40-90 percent of salvianolic acid B, 3.0-15 percent of rosmarinic acid, 2-10 percent of alkannic acid and 0.2-2.2 percent of salvianolic acid E. The invention also provides a preparation containing the extractive and the extractive.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine extract, its preparation and application, in particular to the field of salvia miltiorrhiza extract, its preparation and application. Background technique [0002] In recent years, cardiovascular and cerebrovascular diseases have increased year by year and have become the number one killer of human health. Finding and developing effective drugs for treating cardiovascular diseases has become a hot issue in the field of drug research. Traditional Chinese medicine has received more and more attention because of its good curative effect and small side effects. Among them, Salvia miltiorrhiza and its preparations have been studied more. Salvia miltiorrhiza is the dried root and rhizome of Salvia miltiorrhiza Bunge, a plant in the Labiatae family. It is one of the traditional Chinese medicines for promoting blood circulation and removing stasis, and has a long-term clinical application basi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/10
Inventor 岳洪水
Owner TIANJIN TASLY ZHIJIAO PHARMA
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