Preferential three-step method of production process for diclofenac sodium mucilage

Abstract

The invention discloses an optimum production process for selecting diclofenac sodium mucilage through a preferential three-step method, so as to make sure that the diclofenac sodium mucilage has the characteristics of stable content, homogeneity , no crystallization, no layering, no mildewing, long-term storage, less adverse reactions and the like, thereby providing scientific basis for preparing the high-quality diclofenac sodium mucilage. The preferential three-step method includes the following three steps: six production processes are preliminarily defined, comparing preference is carried out on the diclofenac sodium mucilage prepared by the six production processes, and further preference is carried out on the diclofenac sodium mucilage with different antiseptic content.

Description

technical field [0001] Diclofenac sodium, also known as diclofenac, belongs to a large variety of anti-inflammatory, antipyretic, and analgesic drugs. Background technique [0002] At present, diclofenac sodium has been marketed as tablets, suppositories, liniments, etc. While using various dosage forms to treat diseases, people pay more attention to the maximum absorption of diclofenac sodium, the fastest curative effect, the least gastrointestinal irritation, and the best toxicity control. For this reason, people try to change the dosing To achieve the above purpose, such as rectal administration, this route has the above advantages. Although the rectal administration of diclofenac sodium suppository can improve the curative effect of the drug and reduce adverse drug reactions, the absorption of diclofenac sodium suppository is often affected by the depth of the suppository inserted into the anus, the concentration of body fluids in the rectum, and the rate of dissolution...

AI Technical Summary

Problems solved by technology

In order to make diclofenac sodium, a large variety, high-quality, high-efficiency and safe anti-inflammatory, antipyretic and analgesic drugs, account for a significant increase in the proportion of pharmaceutical production and sales, and make my country's pharmaceutical industry structure more reasonable and more competitive in the market In 2005, we applied for a scientific research project in Xuzhou City: Research on Diclofenac Sodium Mucilage (Xuzhou Science and Technology Development Fund X2005F417), and declared a national patent (application number: 200510006946 X), but this patent only disclosed the final result. However, it does not disclose how to screen and optimize the process and formula