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Application of notoginseng saponin rgl in preparation of medicine for treating pulmonary interstitial fibrosis

A technology of pulmonary interstitial fibrosis and notoginseng saponin, applied in the field of application of notoginseng saponin Rgl in the preparation of drugs for the treatment of pulmonary interstitial fibrosis, can solve the problems of high incidence of IPF, achieve good therapeutic effect, and have obvious pharmacological effects , The effect of simple preparation method

Inactive Publication Date: 2011-11-30
XINXIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The incidence of IPF in my country is relatively high, and there is no completely effective drug at present, but notoginseng saponin Rg1 has a significant effect and less side effects, and has a strong development prospect

Method used

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  • Application of notoginseng saponin rgl in preparation of medicine for treating pulmonary interstitial fibrosis
  • Application of notoginseng saponin rgl in preparation of medicine for treating pulmonary interstitial fibrosis
  • Application of notoginseng saponin rgl in preparation of medicine for treating pulmonary interstitial fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 10

[0025] The preparation of embodiment 1 notoginsenoside Rg1 tablet (1000)

[0026] Prescription: Notoginsenoside Rg1 (Kunming Pharmaceutical Factory, the following examples are all the same) 100g, MCC 100g, magnesium stearate 5g.

[0027] Preparation method: Mix notoginseng saponin Rg1 and MCC evenly, moisten with water, pass through a 18-mesh sieve, dry, pass through a 20-mesh sieve again, then add magnesium stearate, mix evenly, and press into tablets.

Embodiment 2 10

[0028] The preparation of embodiment 2 notoginsenoside Rg1 tablet (1000)

[0029] Formula: notoginseng saponin Rg1100g, lactose 120g, carboxymethylcellulose sodium 24g, magnesium stearate 5g.

[0030] Preparation method: mix notoginseng saponin Rg1, lactose and sodium carboxymethylcellulose evenly, moisten with water, pass through a 18-mesh sieve, dry, pass through a 20-mesh sieve again, then add magnesium stearate, mix well, and press into tablets .

Embodiment 3 3

[0031] The preparation of embodiment 3 notoginseng saponin Rg1 capsules (1000 grains)

[0032] Formula: notoginseng saponin Rg1100g, lactose 80g, magnesium stearate 5g.

[0033] Preparation method: mix notoginseng saponin Rg1 and lactose evenly, moisten with water, pass through a 20-mesh sieve, dry, pass through a 22-mesh sieve again, then add magnesium stearate, mix evenly, and pack into capsules.

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Abstract

The invention provides the application of notoginseng saponin Rg1 in the preparation of medicine for treating pulmonary interstitial fibrosis. The present invention has been verified by pharmacological tests that notoginseng saponin Rg1 can inhibit the activity of human embryonic lung fibroblasts in vitro, and has a good dose dependence; in vivo, it can reduce the lung coefficient and lung tissue hydroxyprophylaxis in mice with pulmonary interstitial fibrosis. It can also reduce the degree of alveolitis and pulmonary fibrosis in mice with pulmonary interstitial fibrosis; and the raw material of notoginseng saponin Rg1 is easy to get, and can be made into various commonly used dosage forms by conventional methods, such as tablets, Capsules, injections, etc., the preparation method is simple.

Description

technical field [0001] The invention relates to the application of notoginseng saponin Rg1 in the preparation of medicines for treating pulmonary interstitial fibrosis. Background technique [0002] Idiopathic pulmonary fibrosis (IPF) refers to pulmonary interstitial lesions caused by unknown causes, characterized by diffuse alveolitis and alveolar structural disorder, eventually leading to pulmonary interstitial fibrosis. Pulmonary interstitial fibrosis often ends with permanent loss of respiratory function. At present, there is no effective prevention and treatment method, which seriously threatens the life and quality of life of patients. The disease of acute patients develops rapidly. The rate is also very low; and chronic patients only have a course of disease of about 15 years. [0003] The morbidity and mortality of idiopathic pulmonary interstitial fibrosis and pulmonary interstitial fibrosis with definite etiology (such as infection, poison, drug, environmental pol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/704A61P11/00
Inventor 詹合琴郭兰青张小毅尹雅玲海广范刘巨源刘俊扇
Owner XINXIANG MEDICAL UNIV
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