Application of hyperin in preparation of medicament for treating diabetes

A diabetes drug, the technology of hyperoside, applied in the field of biomedicine, can solve the problem of hyperoside that has not yet been seen

Inactive Publication Date: 2010-06-30
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, there is no report on the use of hyperoside for hypoglycemia

Method used

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  • Application of hyperin in preparation of medicament for treating diabetes
  • Application of hyperin in preparation of medicament for treating diabetes
  • Application of hyperin in preparation of medicament for treating diabetes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 hypoglycemic pharmacodynamic experiment

[0018] 1 material

[0019] 1.1 Experimental animals: adult Kunming male mice, weighing 20±2g

[0020] 1.2 Drugs and reagents

[0021] Hyperin drug preparation: take 500mg of powder and dissolve in 20ml of distilled water. Positive drug: Jiangtangling (phenformin tablet), 250mg / tablet. When in use, take 1 tablet (250mg) of Jiangtangling, grind it into pieces, and add water to 30ml. Alloxan: HONG KONG FARC0Chemical Supplies product batch number 42011-3E; blood glucose kit: product of Zhongsheng Beikong Biotechnology Co., Ltd., batch number 24011; SOD kit: product of Nanjing Jiancheng Bioengineering Research Institute, batch number 20030123; MDA kit : product of Nanjing Jiancheng Institute of Bioengineering, batch number 20030107; rabbit anti-mouse Insulin immunohistochemical staining kit: product of Tianjin Haoyang Biological Products Technology Co., Ltd.

[0022] 1.3 Main instruments

[0023] Finnish MK-3 micro...

Embodiment 2

[0035] Example 2 Clinical Observation of 30 Cases of Diabetes Treated by Hyperin Capsules

[0036] 1. Clinical data

[0037] 1.1 General Information

[0038] A total of 30 cases, including 18 males and 12 females; aged 13-73 years, with an average age of 51.55 years, the course of the disease is half a month to 12 years, with an average of 5.23 years

[0039] 1.2 Diagnosis and case selection criteria

[0040] 30 cases of diabetic patients, including 4 cases of type I diabetes and 26 cases of type II diabetes. The selected cases were diabetic patients poorly controlled by simple diet control, exercise therapy and drug therapy (including oral hypoglycemic agents and insulin).

[0041] 2. Treatment method

[0042] 2.1 The main ingredients of the drug

[0043] Hyperin Capsules (Containing Hyperin 50mg / capsule)

[0044] 2.2 Treatment methods

[0045] On the basis of diet and exercise therapy, the original dosage remains unchanged. Take hyperoside capsules 2 capsules / time, 3 / ...

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PUM

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Abstract

The invention discloses a new application of hyperin, in particular to an application in the preparation of a medicament for treating diabetes.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new drug application of hyperoside, in particular to the application of hyperin in the preparation of medicines for treating diabetes. Background technique [0002] Hyperin (Hyperin, Hyperoside, Hyp), also known as quercetin-3-O-13-D galactopyranoside, belongs to flavonol glycosides. The aglycone is quercetin, and the glycosyl is galactopyranose, which is connected to the glycosyl by the 3-position O atom of quercetin through a β-glycosidic bond. Widely present in various plants, such as the fruits and whole plants of Hypericaceae, Rosaceae, Platycodonaceae, Labiatae, Berberidaceae, Rhododendronaceae, Sunflower, etc. Its chemical structural formula is shown in the accompanying drawings of the description. [0003] Modern pharmacological research shows that hyperoside has a variety of pharmacological activities. Generally speaking, the pharmacological effects reported in the published ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10
Inventor 张玲凌沛学尚立霞吴永霞曲延伟
Owner 凌沛学
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