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Desmodium-capillary artemisia cholecystagogue, preparation method and quality control method thereof

A kind of drug, the technology of Yinchen, applied in the field of Jinyin choleretic drugs, can solve the problems such as affecting the therapeutic effect, the dosage is not obvious, and the stomach hurts the spleen.

Active Publication Date: 2010-06-30
重庆赛诺生物药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] (1). There are many flavors of traditional Chinese medicine in the prescription, at least more than five flavors. Due to the large number of medicinal flavors, the produced Chinese patent medicine has complex ingredients, more impurities, and unstable quality, which is not conducive to control and increases the burden on patients.
And the prescription contains a lot of bitter and cold products, long-term use of bitter and cold products will damage the stomach and spleen, and spleen and stomach dysfunction will further affect the therapeutic effect
[0004] (2). Money grass and Yinchen are not the king medicines in the prescription, but only adjuvant medicines
There is no obvious study on the dosage of the two
[0005] (3). There is no clear distinction between the availability and quality of capillary medicinal materials, while the Pharmacopoeia clearly distinguishes between picking in spring and harvesting in autumn
[0007] (5). Most of the excipients contain sucrose, which is limited for diabetic patients or elderly patients

Method used

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  • Desmodium-capillary artemisia cholecystagogue, preparation method and quality control method thereof
  • Desmodium-capillary artemisia cholecystagogue, preparation method and quality control method thereof
  • Desmodium-capillary artemisia cholecystagogue, preparation method and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Screening experiment of medicinal flavor compatibility synergy and medicinal flavor ratio

[0028] Using p-xylene-induced ear swelling in mice and the effect on bile secretion in mice, the anti-inflammatory and choleretic effects of Desmodium syringae alone and in combination with capillary wormwood were investigated. The results are shown in Table 1. Dosage is based on the provisions of "Chinese Pharmacopoeia" 2005 Edition, Part One, Desmodium chinensis [Usage and Dosage] 15-60g; Capillaris [Usage and Dosage] 6-15g.

[0029] Table 1: Experiments on the effects of the combination of Desmodium and capillary and the use of p-xylene in different proportions on ear swelling in mice and bile secretion in mice

[0030]

[0031] It can be known from the above table: In terms of the effect on bile secretion (the larger the value, the better) and the anti-inflammatory effect of p-xylene on the ear swelling of mice (the smaller the value, the better), Desmodium and ...

Embodiment 2

[0033] Embodiment 2: extraction process screening experiment

[0034] In this group of examples, 1000g of Desmodium chinensis and 500g of capillary wormwood were put into each experiment, and extracted according to the scheme in the table below. The results are shown in Table 2 and Table 3, and 3 batches of verifications have been carried out according to the extraction scheme screened out, and the extraction process of this invention patent has been obtained: the medicinal materials are put in at a ratio of 2: 1 for Desmodium sativa and Capsicum mellifera, and each addition 10 times the amount of water, decoct three times, 1.5 hours each time, filter the decoction, combine the filtrates, concentrate under reduced pressure to an extract with a relative density of 1.10-1.20.

[0035] Table 2: Factor Level Table

[0036]

[0037] Table 3: Orthogonal experiment design table and results

[0038]

[0039] Analysis of variance will be used in the results of the orthogonal ex...

Embodiment 3

[0043] Embodiment 3: Extraction purification process screening experiment

[0044] In this group of examples, the clear paste is obtained by extracting the best extraction process screened out, and then press L 9 (3 4 ) Orthogonal experimental design table for alcohol precipitation, filtration. Ethanol was recovered from the filtrate under reduced pressure, and the content of chlorogenic acid in the obtained extract was measured, and the amount of chlorogenic acid in the extract was calculated as an evaluation index.

[0045] Table 5 Factor level table

[0046]

[0047] Form 6L 9 (3 4 ) Orthogonal test design table and results

[0048]

[0049]

[0050] The results of the orthogonal experiment were analyzed by variance, and the results are shown in Table 7

[0051] Table 7 variance analysis table

[0052]

[0053] As can be seen from the results in the table above, its main influencing factors are A (the ethanol concentration of the medicinal solution), foll...

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Abstract

The invention relates to a desmodium-capillary artemisia cholecystagogue. The medicinal components of the cholecystagogue comprise desmodium and capillary artemisia of which the weight ratio is 1-4:1, wherein the capillary artemisia is capillary wormwood. The preparation method comprises the following steps: decocting the desmodium and the capillary wormwood in water, carrying out the alcohol precipitation with ethanol and purifying, adding medicinal carrier, making into particles, or pressing the particles into tablets, or encapsulating the particles into capsules, and sub-packaging to obtain a product. The quality control method comprises a method for discriminating the desmodium-capillary artemisia cholecystagogue and a method for determining the content of chlorogenic acid in the desmodium-capillary artemisia cholecystagogue, wherein the method for discriminating the desmodium-capillary artemisia cholecystagogue refers to the thin-layer discrimination of the desmodium and the capillary artemisia; and the content standard is as follows: the dose at one time is equivalent to no less than 3.0mg of capillary artemisia (measured by chlorogenic acid C16H18O9) contained in the desmodium-capillary artemisia cholecystagogue.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, in particular to a Jinyin choleretic medicine for treating cholecystectomy syndrome and simple cholecystitis, which is composed of Desmodium chinensis and capillary wormwood; the invention also relates to the preparation method and quality control of the medicine method. Background technique [0002] Cholecystitis is a common and frequently-occurring disease. Traditional medicine believes that cholecystitis is mostly caused by improper diet, abnormal cold and heat, poor emotions, and internal invasion of external pathogens. The incidence of cholecystitis with gallstones in my country is increasing at a rate of 800,000 new patients every year. The sickness rate of gallstone reaches more than 10%, and is rising year by year (the sickness rate in some foreign regions is even more up to more than 16%). Surgery is often used in the treatment of cholelithiasis in our country, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/16A61K9/20A61P1/16G01N30/90G01N30/02
Inventor 刘悉承黄群英
Owner 重庆赛诺生物药业股份有限公司
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