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Omeprazole sodium combined medicament and preparation method thereof

A technology of omeprazole sodium and medicine, which is applied in the field of combined medicine of omeprazole sodium and its preparation, can solve problems such as damage reaction, allergic reaction, adverse reaction to the liver, etc., so as to improve internal quality, avoid allergic reaction, Reduce the effect of liver damage

Inactive Publication Date: 2010-07-07
蔡海德
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the existing omeprazole sodium preparations that are prone to cause allergic reactions, adverse reactions, and liver damage reactions after taking the existing omeprazole sodium preparations, the invention provides a combination drug of omeprazole sodium

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0027] Omeprazole sodium: 17.3

[0028] Reduced Glutathione 8.7

[0029] Monosodium glutamate 43.5

[0030] The preparation method of above-mentioned combination medicine is as follows:

[0031] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0032] (2). The solution obtained by the membrane ultrafiltration step (1) with a molecular weight cut-off of 8000D, the filtrate is ultrafiltered by a membrane with a molecular weight cut-off of 1500D, and the filtrate is adjusted to a pH value of 7.2 to 7.6 with 8% sodium hydroxide solution.

[0033] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C. for 20 ...

Embodiment 2

[0052] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0053]Omeprazole sodium: 34.8

[0054] Reduced Glutathione 13.0

[0055] Sodium glutamate 52.2

[0056] The preparation method of above-mentioned omeprazole sodium combination medicine is:

[0057] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0058] (2). Be the solution that the membrane ultrafiltration step (1) that molecular weight cut off is 8000D obtains, and filtrate is the membrane ultrafiltration of 1500D with molecular weight cut off, and filtrate is regulated pH value to 7.2~7.6 with 8% sodium hydroxide solution.

[0059] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C. for 20 minutes...

Embodiment 3

[0077] The omeprazole sodium combination medicine provided by the present embodiment comprises the following medicinal ingredients in parts by weight:

[0078] Omeprazole sodium: 29.1

[0079] Reduced Glutathione 10.2

[0080] Monosodium glutamate 46.3

[0081] The preparation method of above-mentioned omeprazole sodium combination medicine is:

[0082] (1). Take water for injection whose weight is 50 to 125 times of the weight of the omeprazole sodium, and dissolve the omeprazole sodium, reduced glutathione and sodium glutamate respectively under stirring Completely, get a solution of the drug.

[0083] (2). The solution obtained by the membrane ultrafiltration step (1) with a molecular weight cut-off of 8000D, the filtrate is ultrafiltered by a membrane with a molecular weight cut-off of 1500D, and the filtrate is adjusted to a pH value of 7.2 to 7.6 with 8% sodium hydroxide solution.

[0084] (3). The solution obtained in step (2) was sterilized by moist heat at 121° C....

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PUM

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Abstract

The invention discloses an omeprazole sodium combined medicament and a preparation method thereof. The omeprazole sodium combined medicament comprises the following medicinal effect compositions in part by weight: 17.3 to 34.8 parts of the omeprazole sodium, 8.7 to 13.0 parts of reduced glutathione and 43.5 to 52.2 parts of sodium glutamate. The omeprazole sodium combined medicament provided by the invention has the effect of resisting drug allergy and can lighten the damage effect and the adverse reaction of the omeprazole sodium on liver; the medicament has high quality; and the preparation method is energy-saving and environment-friendly.

Description

technical field [0001] The invention relates to a combination medicine of omeprazole sodium and a preparation method thereof. Background technique [0002] The gastric and duodenal mucosa has a natural and perfect mechanism to resist the erosion of gastric acid and pepsin, but when it is damaged by Helicobacter pylori and non-steroidal anti-inflammatory drugs, peptic ulcer disease will occur. Australian scholars Warren and Marshall revealed this etiology, and used H 2 Receptor antagonist therapy drugs were effectively treated, and 22 years later, the two were awarded the 2005 Nobel Prize in Medicine. In the 1980s, there were studies on the treatment of peptic ulcer disease with proton pump inhibitors, which were more effective than H 2 Inhibitor treatments are more powerful and long-lasting. Omeprazole sodium is a typical representative drug, and it is one of the first-selected drugs for the treatment of peptic ulcer disease. But, all adopt activated carbon depyrogenatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4439A61K47/42A61K47/16A61P1/04A61K47/18
Inventor 蔡海德
Owner 蔡海德
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