Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy
A technology for diabetic nephropathy and total flavonoids is applied in the application field of astragalus total flavonoids in the preparation of medicines for preventing and treating diabetic nephropathy, and can solve the problems of no reports and the like
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0020] Embodiment 1 Astragalus total flavonoids and monomer compound preparation
[0021] Take 10 kg of dried Astragalus medicinal material, reflux extract with 8 times the amount of 80% ethanol for 3 times (2 hours, 1 hour, 1 hour), filter, combine the filtrates, recover the solvent under reduced pressure, concentrate until no alcohol smell, and obtain the alcohol extract of Astragalus. Put it in a refrigerator at 4°C for 2 days, absorb the supernatant with D101 macroporous resin, elute with pure water until the effluent is clear, and then elute with 50% ethanol until no ascoside spots are detected by TLC. Collect 50% ethanol eluate, concentrate under reduced pressure, extract 7 times with equal volume of ethyl acetate, combine the extracts, recover the solvent, and dry in vacuum to obtain the total flavonoids of Radix Astragali. The content of total flavonoids detected by ultraviolet spectrophotometry was 54.3%.
[0022] The total flavonoids of Radix Astragali was then chro...
Embodiment 2
[0023] Embodiment 2 Astragalus total flavonoids and monomer compound preparation
[0024] Take 100 kg of dried Radix Astragali medicinal material, extract 3 times (2 hours, 1 hour, 0.5 hour) respectively with 10 times the amount of 80% ethanol, 5 times the amount of 60% ethanol, and 5 times the amount of 90% ethanol, filter, combine the filtrates, and decompress Recover the solvent, concentrate until there is no alcohol smell, and obtain the ethanol extract of astragalus, put it in a refrigerator at 4°C for 1 day, and absorb the supernatant with AB-8 macroporous resin, first elute with pure water until the effluent is clear, and then use Elute with 40% ethanol until no verbascoside spots are detected by TLC. Collect 40% ethanol eluate, concentrate under reduced pressure, extract 7 times with equal volume of ethyl acetate, combine the extracts, recover the solvent, and dry in vacuum to obtain the total flavonoids of Radix Astragali. The content of total flavonoids detected by ...
Embodiment 3
[0026] Embodiment 3 contains the capsule (tablet) of astragalus total flavonoids
[0027] Preparation prescription:
[0028] Astragalus total flavonoids 80g
[0029] Microcrystalline Fiber 80g
[0030] Starch 20g
[0031] Lactose 18g
[0032] Dextrin 2g
[0033] Preparation method: take the total flavonoids extract of Radix Astragali prepared in Example 1, pulverize it, pass through an 80-mesh sieve, mix it with the above-mentioned auxiliary materials evenly, granulate it with 80% ethanol, and granulate it; take half of it and pack it into capsules to make 500 capsules; One half is compressed into tablets to make 500 pieces.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com