Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy

A technology for diabetic nephropathy and total flavonoids is applied in the application field of astragalus total flavonoids in the preparation of medicines for preventing and treating diabetic nephropathy, and can solve the problems of no reports and the like

Active Publication Date: 2012-05-30
广州康臣药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Although it has been reported in the literature that it has various pharmacological activities, however, there is no report at home and abroad on the effect of total flavonoids of Astragalus on the prevention and treatment of diabetic nephropathy.

Method used

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  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy
  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy
  • Application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Astragalus total flavonoids and monomer compound preparation

[0021] Take 10 kg of dried Astragalus medicinal material, reflux extract with 8 times the amount of 80% ethanol for 3 times (2 hours, 1 hour, 1 hour), filter, combine the filtrates, recover the solvent under reduced pressure, concentrate until no alcohol smell, and obtain the alcohol extract of Astragalus. Put it in a refrigerator at 4°C for 2 days, absorb the supernatant with D101 macroporous resin, elute with pure water until the effluent is clear, and then elute with 50% ethanol until no ascoside spots are detected by TLC. Collect 50% ethanol eluate, concentrate under reduced pressure, extract 7 times with equal volume of ethyl acetate, combine the extracts, recover the solvent, and dry in vacuum to obtain the total flavonoids of Radix Astragali. The content of total flavonoids detected by ultraviolet spectrophotometry was 54.3%.

[0022] The total flavonoids of Radix Astragali was then chro...

Embodiment 2

[0023] Embodiment 2 Astragalus total flavonoids and monomer compound preparation

[0024] Take 100 kg of dried Radix Astragali medicinal material, extract 3 times (2 hours, 1 hour, 0.5 hour) respectively with 10 times the amount of 80% ethanol, 5 times the amount of 60% ethanol, and 5 times the amount of 90% ethanol, filter, combine the filtrates, and decompress Recover the solvent, concentrate until there is no alcohol smell, and obtain the ethanol extract of astragalus, put it in a refrigerator at 4°C for 1 day, and absorb the supernatant with AB-8 macroporous resin, first elute with pure water until the effluent is clear, and then use Elute with 40% ethanol until no verbascoside spots are detected by TLC. Collect 40% ethanol eluate, concentrate under reduced pressure, extract 7 times with equal volume of ethyl acetate, combine the extracts, recover the solvent, and dry in vacuum to obtain the total flavonoids of Radix Astragali. The content of total flavonoids detected by ...

Embodiment 3

[0026] Embodiment 3 contains the capsule (tablet) of astragalus total flavonoids

[0027] Preparation prescription:

[0028] Astragalus total flavonoids 80g

[0029] Microcrystalline Fiber 80g

[0030] Starch 20g

[0031] Lactose 18g

[0032] Dextrin 2g

[0033] Preparation method: take the total flavonoids extract of Radix Astragali prepared in Example 1, pulverize it, pass through an 80-mesh sieve, mix it with the above-mentioned auxiliary materials evenly, granulate it with 80% ethanol, and granulate it; take half of it and pack it into capsules to make 500 capsules; One half is compressed into tablets to make 500 pieces.

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Abstract

The invention relates to the pharmacy field of traditional Chinese medicines, in particular to application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy. The invention investigates the influence of the total flavonoid in astragalus on the cell proliferation and the cell extracellular matrix hyperplasia of a glomerulus mesentery of a rat as well as the therapeutic effect of the total flavonoid in astragalus on a mouse with the diabetes and the nephropathy; and the experimental result proves that the total flavonoid in astragalus has remarkable treating and preventing functions on the diabetes and the nephropathy, thus the invention provides application of total flavonoid in astragalus to preparing medicaments for preventing and controlling diabetes and nephropathy and a medicinal composition which contains the total flavonoid in astragalus and is used for preventing and controlling the diabetes and the nephropathy, andthereby providing a new medicine choice for treating and preventing the diabetes and the nephropathy.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine pharmacy, in particular to the application of astragalus total flavonoids in the preparation of medicines for preventing and treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy (diabetic nephropathy, DN), also known as "diabetic glomerulosclerosis", is a common complication of diabetes and one of the manifestations of diabetic systemic microangiopathy, usually due to thickening of the glomerular basement membrane caused by diabetes, Mesangial expansion and extracellular matrix hyperplasia lead to glomerulosclerosis. Mesangial cell lesions play an extremely important role in the occurrence and development of diabetic nephropathy. Glomerular mesangial cells are the main component of glomeruli, accounting for about 30-40% of the total number of glomerular cells. Glomerular mesangial cells have multiple functions, such as secreting cell matrix, producing cytok...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/481A61P3/10A61P13/12
Inventor 朱荃石兴华汤丹郑兆广何宝段婷婷顾斐程慧荃黄晓玲黄艳霞王汝上
Owner 广州康臣药业有限公司
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