Medicinal composition for curing hemorrhoids and preparation method thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of inconvenience in people's daily life, difficult to cure hemorrhoids and other problems, and achieve good effects and mild side effects.

Active Publication Date: 2010-09-22
四川梓橦宫药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hemorrhoids generally do not cause great harm, they still have an inconvenient impact on people's daily life
At present, the methods for treating hemorrhoids include surgical treatment, acupuncture treatment, exercise therapy and drug therapy. Various treatment methods occupy a very important position in the treatment, but the intractability of hemorrhoids still causes great trouble and pain to people.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The dosage of the medicine embodiment of the present invention is as follows (weight ratio):

[0026] 36% polycresol solution 11.17%, diobucaine hydrochloride 0.10%, 20% sodium hydroxide solution 4.44%, mixed fatty acid glycerides 60.80%, lanolin 14.15%, calcium sulfate (dihydrate) 9.34%.

[0027] A preparation method of anhydrous medicament group for treating hemorrhoids, comprising the steps of:

[0028] Step 1, according to the above formula, weigh 36% polycresol solution, adjust the pH value to 2.7 to 3.3 with 20% sodium hydroxide solution, then concentrate under reduced pressure at 50°C to make the polycresol solution The concentration is 60%, adding calcium sulfate, stirring evenly, transferring it to a baking tray, drying under reduced pressure at 50°C, then pulverizing, and passing through a 80-mesh sieve to obtain polycresol fine powder;

[0029] Step 2, after pulverizing Dibucaine Hydrochloride, pass through a 100-mesh sieve;

[0030] Step 3, mix the policre...

Embodiment 2

[0034] The dosage of the medicine embodiment of the present invention is as follows (weight ratio):

[0035] 36% polycresol solution 14%, Dibucaine hydrochloride 0.13%, 20% sodium hydroxide solution 4.39%, Mixed fatty acid glycerides 61.39%, Anhydrous lanolin 13.15%, Calcium sulfate (dihydrate) 8.77%.

[0036] A preparation method for a pharmaceutical composition for the treatment of hemorrhoids, comprising the steps of:

[0037] Step 1, according to the above formula, weigh 36% polycresol solution, adjust the pH value to 2.7 to 3.3 with 20% sodium hydroxide solution, then concentrate under reduced pressure at 45°C to make the polycresol solution Add calcium sulfate at a concentration of 60%, stir evenly, transfer it to a baking tray, dry under reduced pressure at 45°C, then pulverize, pass through a 90-mesh sieve to obtain polycresol fine powder;

[0038] Step 2, after pulverizing Dibucaine Hydrochloride, pass through a 100-mesh sieve;

[0039] Step 3, mix the policresol fi...

Embodiment 3

[0043] The dosage of the medicine embodiment of the present invention is as follows (weight fraction):

[0044] 36% polycresol solution 13.8%, Dibucaine hydrochloride 0.5%, 20% sodium hydroxide solution 4.12%, Vaseline 59.94%, Beeswax 2.30%, Anhydrous lanolin 11.56%, Calcium sulfate (dihydrate) 9.12%.

[0045] A preparation method for a pharmaceutical composition for the treatment of hemorrhoids, comprising the steps of:

[0046] Step 1, according to the above formula, weigh 36% polycresol solution, adjust the pH value to 2.7 to 3.3 with 20% sodium hydroxide solution, then concentrate under reduced pressure at 50°C to make the polycresol solution The concentration is 60%, adding calcium sulfate, stirring evenly, transferring it to a baking tray, drying under reduced pressure at 50°C, then pulverizing, and passing through a 80-mesh sieve to obtain polycresol fine powder;

[0047] Step 2, after pulverizing Dibucaine Hydrochloride, pass through a 100-mesh sieve;

[0048] Step 3...

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PUM

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Abstract

The invention discloses a medicinal composition for curing hemorrhoids, which is a compound preparation prepared by mixing policresulen and cinchocaine hydrochloride serving as active ingredients, and pharmaceutically acceptable auxiliary materials serving as carriers. The weight of the policresulen in medicinal composition accounts for 3 to 10 percent of the total weight of the composition, and the weight of the cinchocaine hydrochloride accounts for 0.1 to 0.8 percent of the total weight of the composition. The invention also discloses a preparation method of the medicinal composition for curing the hemorrhoid. The policresulen serving as a main active material has the effects of stopping bleeding, converging, regenerating epithelium and sterilizing to make necrotic tissues coagulated and separated so as to quickly clean wounds. Meanwhile, due to the adoption of the composition, strong reactive contrafluxion is generated so as to promote the tissues to regenerate. The medicinal composition carries out local anesthesia by adopting the quick-acting cinchocaine hydrochloride for suppressing pain of wounds. The medicinal composition is prepared into an external preparation, which comprises suppository, ointments and the like. The medicinal composition is suitable for curing hemorrhoids, anal fissure and rhagadia, pruritus ani and the like.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hemorrhoids, which is a pharmaceutical composition formed by mixing polycresol and dibucaine hydrochloride active ingredients with pharmaceutically acceptable auxiliary materials as carriers, and the pharmaceutical composition The preparation method of the composition belongs to the technical field of medicine. Background technique [0002] Hemorrhoids is a common anorectal disease, its incidence rate accounts for 87.25% of all anorectal diseases, both men and women can get this disease, the incidence rate of women is 67%, and the incidence rate of men is 53.9%; it can occur at any age, of which 20 It is more common in people over 40 years old, and it will gradually increase with age, so there is a saying that "nine out of ten people have hemorrhoids". There are many causes of the disease. When a person is standing or sitting, the anorectum is located in the lower part. Due to the pres...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/795A61K31/47A61P9/14
Inventor 陈健唐铣黄学兵
Owner 四川梓橦宫药业股份有限公司
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