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Vitexin-2''-O-rhamnoside pill and preparation method

A technology of rhamnoside and vitexin, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., can solve the problem of no in-depth research on new drugs, and achieve fast absorption, broad market prospects, and easy portability Effect

Inactive Publication Date: 2010-10-06
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no in-depth research on the development of new drugs with its active monomer components

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of vitexin-2″-O-rhamnoside dripping pills, which is to add vitexin-2″-O-rhamnoside raw material medicine and matrix into melted PEG1500 and PEG4000 according to the ratio of 1:1 (PEG1500: PEG4000 = 1: 1), stirring continuously to make a uniform molten medicinal solution. Transfer to the liquid storage bottle, adjust the temperature control system of the dropping pill machine to keep the temperature of the dropping pill at 80°C to 90°C. The melted material will drop into the liquid paraffin at an appropriate speed through the dropper of the dropping pill machine. The temperature of liquid paraffin is controlled at 5°C to -5°C. The oil pellets are separated, the dripping pills at the outlet of the dripping pill machine are taken out, the surface condensing agent is removed, and dried under suitable temperature and humidity conditions to obtain the product.

Embodiment 2

[0019] A preparation method of vitexin-2″-O-rhamnoside dripping pills, which is to add vitexin-2″-O-rhamnoside raw material medicine and matrix into melted PEG1000 and PEG6000 according to the ratio of 1:1 (PEG1000: PEG6000 = 1: 1), stirring continuously to make a uniform molten medicinal solution. Transfer to the liquid storage bottle, adjust the temperature control system of the dropping pill machine to keep the temperature of the dropping pill at 80°C to 90°C. The melted material will drop into the liquid paraffin at an appropriate speed through the dropper of the dropping pill machine. The temperature of liquid paraffin is controlled at 5°C to -5°C. The oil pellets are separated, the dripping pills at the outlet of the dripping pill machine are taken out, the surface condensing agent is removed, and dried under suitable temperature and humidity conditions to obtain the product.

Embodiment 3

[0021] A preparation method of vitexin-2″-O-rhamnoside dripping pills is to add vitexin-2″-O-rhamnoside raw material drug and matrix into molten PEG4000 in a ratio of 1:2, Stir continuously to make a uniform molten liquid medicine. Transfer to the liquid storage bottle, adjust the temperature control system of the dropping pill machine to keep the temperature of the dropping pill at 85°C to 95°C. The melted material will drop into the simethicone oil at an appropriate speed through the dropper of the dropping pill machine. The temperature of simethicone oil is controlled at 10℃~-5℃. The oil pellets are separated, the dripping pills at the outlet of the dripping pill machine are taken out, the surface condensing agent is removed, and dried under suitable temperature and humidity conditions to obtain the product.

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PUM

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Abstract

The invention provides a preparation method of vitexin-2''-O-rhamnoside pills, which comprises the following steps: heating hawthorn leaf activated monomer component vitexin-2''-O-rhamnoside and matrix, fusing and stirring evenly; and pouring into a condenser at a certain speed and shrinking the solid solution to prepare into the vitexin-2''-O-rhamnoside pills. The vitexin-2''-O-rhamnoside pills prepared by the invention can be solely or jointly applied to treatment of chest obstruction and heart ache with high efficacy.

Description

technical field [0001] The invention relates to vitexin-2″-O-rhamnoside drop pills, in particular to vitexin-2″-O-rhamnoside, which is an active monomer component of hawthorn leaves, as a medicinal ingredient, polyethylene glycol, Sodium stearate or its mixture is used as a base, and liquid paraffin, simethicone or vegetable oil is used as a condensing agent, a drop pill for treating chest pain and heartache and a preparation method thereof. Background technique [0002] According to the statistics of the Ministry of Health, in recent years, the death toll of cardiovascular disease has accounted for more than one-third of the total death toll in my country, ranking first among the top ten causes of death in urban and rural populations. [1] . The morbidity, disability and mortality of cardiovascular diseases are increasing year by year. In view of the harmfulness of cardiovascular diseases, the World Health Organization has listed it as one of the current overall priorities ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/7048A61P9/10
Inventor 英锡相康廷国张文洁杜洋程忠哲
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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