Method for preparing cefcapene pivoxil hydrochloride
A technology of cefcapine and picoxil, applied in the direction of organic chemistry, can solve the problems of serious environmental pollution and high cost, and achieve the effects of high yield, low cost, great implementation value and potential social and economic benefits
Inactive Publication Date: 2010-10-06
ZHEJIANG HUAFANG PHARMA
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Abstract
The invention relates to a method for preparing cefcapene pivoxil hydrochloride, which comprises the following steps: dissolving Boc-protected cefcapene pivoxil shown by a formula (II) in an organic solvent; dripping 60 to 85 mass percent aqueous solution of phosphoric acid at 15 DEG C below zero to 30 DEG C to perform a de-Boc reaction, stirring the solution, and after the reaction is performed for 1 to 4 hours, and adjusting the pH value of the reaction solution with aqueous solution of sodium hydroxide to 7.0; removing the water layer, and concentrating an organic layer under reduced pressure to recover an organic solvent to obtain an oily material; adding an alcohol solvent into the oily material, controlling the temperature between 10 and 20 DEG C, dripping 5 to 15 mass percent solution of hydrochloric acid to form a salt; and keeping the temperature for 1 to 4 hour, filtering the solution, washing the filter cake with 10 to 50 percent aqueous solution of ethanol, drying the filter cake under vacuum at 45 DEG C till the weight of the filter cake is constant and thus, obtaining the cefcapene pivoxil hydrochloride. The method of the invention is high in yield and low in cost and can reduce environmental pollution generated in the production of the Boc-protected cefcapene pivoxil in source.
Application Domain
Organic chemistry
Technology Topic
SolventFilter cake +12
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