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Antineoplastic medicament extracted from Chinese actinidia roots and preparation method thereof

A technology of Chinese kiwi fruit and extract, which is applied in the direction of antineoplastic drugs, pharmaceutical formulas, drug combinations, etc., to achieve the effect of improving the cure rate and shortening the cure period

Inactive Publication Date: 2010-10-20
郭蕾
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Kiwifruit (A ctin2 id ia deliciosa C1F1 liang et1A1R1Ferguson) is a plant of the Actinidiaceae Actinidia family. The 60% ethanol extract of its root has the effect of inhibiting the growth of tumor cells in vitro [5]. There is no published research report on whether the tumor has an inhibitory effect

Method used

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  • Antineoplastic medicament extracted from Chinese actinidia roots and preparation method thereof
  • Antineoplastic medicament extracted from Chinese actinidia roots and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 extracts the effective part of Actinidia sinensis root

[0048] Take 1000 grams of kiwifruit root slices, wash them, add 5 times the amount of 30% ethanol and impregnate twice, each time for 24 hours, let stand, take the supernatant, combine, add ethanol to adjust the ethanol content to 72%, let stand Centrifuge for 24 hours, wash the precipitate with 5 times the amount of 72% ethanol and absolute ethanol once, discard the washing solution, wash the precipitate with 3 times the amount of ether once, discard the ether solution, and dry the precipitate at room temperature under reduced pressure . Grind to obtain 100 grams of powder.

Embodiment 2

[0049] Embodiment 2 prepares medicine eye drops of the present invention

[0050] Take the coarse powder prepared in Example 1, add water for injection to dissolve, first stir with an emulsifier at 10,000 rpm for 3 minutes, centrifuge at 25,000 rpm for 1 hour, pour out the supernatant, add an appropriate amount of water for injection to the sediment, and then centrifuge for 1 hour. Get supernatant and previous supernatant and merge, then, through microporous membrane classification filtration again, get the filtrate under 0.45 μ filter membrane, add 0.03% ethylparaben and appropriate amount of sodium chloride (sodium chloride The added amount is the amount required for the finished product to reach isotonic pressure), add water for injection to adjust to a solution containing 1 mg of polysaccharide per ml, filter, seal in aseptic pots, and obtain.

Embodiment 3

[0051] The preparation of embodiment 3 pharmaceutical capsules of the present invention

[0052] Take 1000 grams of kiwifruit root slices, wash them, add 5 times the amount of 30% ethanol and impregnate twice, each time for 24 hours, let stand, take the supernatant, combine, add ethanol to adjust the ethanol content to 72%, let stand Centrifuge for 24 hours, wash the precipitate with 5 times the amount of 72% ethanol and absolute ethanol once, discard the washing solution, wash the precipitate with 3 times the amount of ether once, discard the ether solution, and dry the precipitate at room temperature under reduced pressure , pulverized, passed through a 100-mesh sieve to obtain 100 grams of powder, mixed evenly with the obtained medicinal powder and starch in a ratio of 1:1, packed into capsules, and each gram contained 1 gram of medicine.

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Abstract

The invention relates to an antineoplastic medicament extracted from Chinese actinidia roots and a preparation method thereof. Actinidia deliciosa ethyl acetate extracts (ADEE) and actinidia deliciosa n-butanol extracts (ADBE) of the Chinese actinidia roots have an obvious in-vivo antineoplastic function. The invention designs an extracting method and establishes an S180 mouse sarcoma model and an H22 hepatoma ascites tumor model. The ethyl acetate extracts and the n-butanol extracts have the obvious inhibiting function on the growth of an S180 solid tumor and can obviously prolong the survival time of an H22 hepatoma ascites tumor mouse and have a certain immune promoting function. The ADEE and the ADBE of the Chinese actinidia roots have an obvious antineoplastic function in a mouse body.

Description

Background technique [0001] In recent years, many scholars have studied the anti-tumor effect of Actinidia plants in the family Actinidia, and it has been confirmed that the peptidoglycan in the root of Actinidia chinensis, the extract of Actinidia chinensis root and the root extract of Actinidia sorbea all have anti-tumor effects [1 ~4〕. Kiwifruit (A ctin2 id ia deliciosa C1F1 liang et1A1R1Ferguson) is a plant of the Actinidiaceae Actinidia family. The 60% ethanol extract of its root has the effect of inhibiting the growth of tumor cells in vitro [5]. There is no published research report on whether the tumor has an inhibitory effect. In addition, the author found in the previous in vitro experimental research that the ethyl acetate extract and n-butanol extract of kiwifruit root had a significant inhibitory effect on the growth of tumor cells, so this experiment inoculated S180 solid tumor and H22 liver cancer ascites in vivo. The anti-tumor effect of ethyl acetate and n-b...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P35/00A61P1/16A61K125/00
Inventor 郭蕾
Owner 郭蕾
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