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Composition of secnidazole and lactose and preparation method thereof

A technology of secnidazole and composition, which is applied in the field of secnidazole and lactose composition and preparation thereof, and achieves the effects of good clinical effect, good disintegration effect and compressibility

Active Publication Date: 2010-11-03
西安万隆制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, how to determine the dosage and solve the problem of disintegration of drugs is still a subject that R&D practitioners must treat carefully and continue to innovate

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  • Composition of secnidazole and lactose and preparation method thereof
  • Composition of secnidazole and lactose and preparation method thereof
  • Composition of secnidazole and lactose and preparation method thereof

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Embodiment Construction

[0024] See attached figure 1 , the present invention relates to a kind of secnidazole and lactose composition, it is characterized in that, said composition has: secnidazole 500g, lactose 76g, carboxymethyl starch sodium 24g, povidone ethanol liquid Appropriate amount, magnesium stearate 2.8g.

[0025] In addition, if the tablet is made into 50 tablets, it will contain: 25.0 g of secnidazole, 4.2 g of lactose, 0.8 g of sodium starch glycolate, an appropriate amount of ethanol solution of povidone, and 0.13 g of magnesium stearate.

[0026] In addition, if the tablet is made into 50 tablets, it will contain: 25.0 g of secnidazole, 4.0 g of lactose, 1.0 g of sodium starch glycolate, an appropriate amount of povidone ethanol solution, and 0.14 g of magnesium stearate.

[0027] In addition, if the tablet is made into 50 tablets, it will contain: 25.0 g of secnidazole, 3.8 g of lactose, 1.2 g of sodium starch glycolate, an appropriate amount of povidone ethanol solution, and 0.14 ...

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Abstract

The invention relates to a composition of secnidazole and lactose. 1,000 tablets of the composition comprise 500 grams of secnidazole, 76 grams of lactose, 24 grams of sodium starch glycolate, a proper amount of polyvidone ethanol solution and 2.8 grams of magnesium stearate. A preparation method for the composition comprises a stepped production process. In the composition and the method, the lactose is quantitatively selected and used on the basis that the using amount of the secnidazole is determined, and both the secnidazole and the lactose have high fluidity and compressibility and can promote tablet disintegration; and meanwhile, the sodium starch glycolate is quantitatively selected and used as a disintegrating agent to endow the tablet with better disintegration and higher compressibility.

Description

technical field [0001] The invention relates to a nitroimidazole drug in the technical field of medicine and a preparation method of the composition, in particular to a secnidazole and lactose composition and a preparation method thereof. Background technique [0002] According to clinical classification, in gynecology clinics, imidazoles are still the main treatment for fungal vaginitis, bacterial vaginosis or trichomonal vaginitis in gynecological clinics. Because, after all, the vast majority of vaginitis in statistical significance occurs in women with a history of sexual contact, and its proportion is more than half of the visit rate. The current treatment options are mostly divided into two categories from the drug type of administration: oral and topical. In this regard, Chinese patent literature discloses multiple invention patent applications such as publication numbers CN1973838A, CN1679554A, and CN101698101A. The types of administration given by these applicatio...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/20A61K47/26A61K47/36A61P15/02
Inventor 郑方晔刘护鱼周小园於长权
Owner 西安万隆制药股份有限公司
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