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Method for bionically preparing water-soluble gold nanoparticles

A gold nanoparticle and water-soluble technology, which is applied in the fields of chemistry and materials science, can solve the problems of reaction mechanism research, lack of clarity, and difficult control of product morphology, and achieve the effect of mild conditions and good stability

Inactive Publication Date: 2010-11-03
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method of biosynthesis of nanomaterials usually has problems such as difficult control of product morphology and difficulty in purification, and the specific reaction mechanism is not clearly studied, so these methods have not been well promoted.

Method used

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  • Method for bionically preparing water-soluble gold nanoparticles
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  • Method for bionically preparing water-soluble gold nanoparticles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 gold nanoparticles

[0020] (1) 1g chloroauric acid is dissolved in 100mL ultrapure water, is made into the chloroauric acid stock solution of 1% (weight to volume ratio);

[0021] (2) chloroauric acid solution is mixed with reduced glutathione (GSH) in a molar ratio of 1:1;

[0022] (3) The pH value of the reaction solution is adjusted to 2.5-3.0 with sodium hydroxide solution to obtain a pale yellow precipitate;

[0023] (4) centrifugation (RCF 10000g), the precipitate is dissolved with 0.01mol / L sodium hydroxide solution to obtain a gold precursor solution;

[0024] (5) Dilute the gold precursor solution to 0.64 mmol / L with ultrapure water, add NADPH and GR at a ratio of 2 mg NADPH and 1 unit GR per ml of the diluted solution, and stir for 12 hours at room temperature at 25°C;

[0025] (6) The reaction solution was ultrafiltered with an ultrafiltration tube (Millipore) with a molecular weight cut-off of 30 kDa, and components with ...

Embodiment 2

[0026] The preparation of embodiment 2 gold nanoparticles

[0027] (1) 1g chloroauric acid is dissolved in 100mL ultrapure water, is made into 1% chloroauric acid stock solution;

[0028] (2) chloroauric acid solution is mixed with reduced glutathione (GSH) in a molar ratio of 1:1;

[0029] (3) The pH value of the reaction solution is adjusted to 2.5-3.0 with sodium hydroxide solution to obtain a pale yellow precipitate;

[0030] (4) Centrifuge (RCF 10000g) for 3 minutes, and dissolve the precipitate with 35ml of 0.01mol / L sodium hydroxide solution to obtain a gold precursor solution;

[0031] (5) Dilute the gold precursor solution to 0.64mmol / L with ultrapure water, add NADPH and GR at a ratio of 3mg NADPH and 1 unit GR per milliliter of the diluted solution, and stir for 12 hours at room temperature at 25°C;

[0032] (6) The reaction solution was ultrafiltered with an ultrafiltration tube (Millipore) with a molecular weight cut-off of 30 kDa, and components with a molecu...

Embodiment 3

[0033] The preparation of embodiment 3 gold nanoparticles

[0034] (1) 1g chloroauric acid is dissolved in 100mL ultrapure water, is made into 1% chloroauric acid stock solution;

[0035] (2) chloroauric acid solution is mixed with reduced glutathione (GSH) in a molar ratio of 1:1;

[0036] (3) The pH value of the reaction solution is adjusted to 2.5-3.0 with sodium hydroxide solution to obtain a pale yellow precipitate;

[0037] (4) Centrifuge (RCF 10000g) for 3 minutes, and dissolve the precipitate with 35ml of 0.01mol / L sodium hydroxide solution to obtain a gold precursor solution;

[0038] (5) Dilute the gold precursor solution to 0.64 mmol / L with ultrapure water, add NADPH and GR at a ratio of 4 mg NADPH and 1 unit GR per ml of the diluted solution, and stir and react at room temperature 25°C for 12 hours;

[0039] (6) The reaction solution was ultrafiltered with an ultrafiltration tube (Millipore) with a molecular weight cut-off of 30 kDa, and components with a molec...

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Abstract

The invention discloses a method for bionically preparing water-soluble gold nanoparticles. In the method, the water-soluble gold nanoparticles are prepared in the like biological system based on the reduction reaction and enzyme catalysis process in the cells. The method is simple and practicable, the used reagent is environmentally friendly and the controllable gold nanoparticles with uniform size can be obtained under room temperature. With surfaces cladded by a layer of dense glutathione molecules, the products have good stability in the aqueous solution. The method provides a new train of thought for green synthesis of nano materials.

Description

technical field [0001] The invention relates to the fields of chemistry and material science, in particular to a method for preparing water-soluble gold nanoparticles through a bionic green approach. Background technique [0002] Nanoparticles refer to particles with a size between 1 and 100nm, which are located in the transition zone between atomic clusters and macroscopic objects. When the particle size enters the nanometer level, it changes from quantitative to qualitative, and its mechanical, thermal, electrical, magnetic and optical properties undergo fundamental changes. Nanoparticles have a small size and a large surface area, with a large proportion of atoms located on the surface. The atoms on the surface have unsaturated dangling bonds, which are very unstable, which greatly increases the activity of nanoparticles. For example, metal nanoparticles can burn in the air, and nanoparticles of inorganic materials can absorb and react with gases in the environment. Or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24
Inventor 庞代文张明曦崔然田智全张志凌
Owner WUHAN UNIV
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