Lornoxicam hydrogel patch and preparation method thereof

Abstract

The invention discloses a lornoxicam hydrogel patch and a preparation method thereof. In the hydrogel patch, lornoxicam is used as a medicinal active ingredient, and the hydrogel patch consists of a medicament-containing matrix, an adhesive layer, a lining layer and a protective layer, wherein the medicament-containing matrix consists of the lornoxicam, a hydrogel matrix and a penetrating agent. The patch makes the medicament release stably to prolong half-life period, is remarkably superior to other conventional preparations of the lornoxicam, and has the 48-hour accumulated permeation quantity of over 300ug.cm<-2> through percutaneous experiments in vitro. Pharmacodynamic tests prove that the lornoxicam hydrogel patch has excellent effect of relieving pain and diminishing inflammation.

Description

technical field

[0001] The invention relates to a lornoxicam hydrogel patch and a preparation method thereof. Background technique

[0002] Lornoxicam (trade name: Kesaifeng) is a non-steroidal anti-inflammatory drug developed by Nycomed, which belongs to thiazide derivatives and has strong analgesic and anti-inflammatory effects. This drug has been widely used clinically for acute pain after surgery, and can also be used for the treatment of chronic low back pain, osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It has been recommended by WHO as the first step drug to control cancer pain. However, the use of most NSAIDs is limited by the side effects associated with them, especially gastrointestinal side effects. Studies have shown that the incidence of adverse drug reactions caused by the application of lornoxicam injection is about 10%, and the main clinical manifestations are nausea, vomiting, stomach pain, diarrhea and other gastrointestinal reactions....

Images