Lornoxicam hydrogel patch and preparation method thereof

A lornoxicam hydrogel patch and technology of lornoxicam, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of slow drug release and inability to fully meet clinical needs

Active Publication Date: 2010-11-10
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
View PDF3 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent uses fat-soluble pressure-sensitive adhesive as the matrix, and the drug release rate is slow, which cannot fully meet the clinical needs

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Lornoxicam hydrogel patch and preparation method thereof
  • Lornoxicam hydrogel patch and preparation method thereof
  • Lornoxicam hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Embodiment 1, preparation lornoxicam hydrogel patch

[0040] Drug-containing matrix components (per 100cm 2 )

[0041] Lornoxicam (main drug) 0.05g

[0042] Polyvinylpyrrolidone K90 (skeleton material) 1.05g

[0043] Polyvinylpyrrolidone K30 (skeleton material) 0.78g

[0044] Polyvinyl alcohol-124 (skeleton material) 0.26g

[0045] Aluminum trichloride (crosslinking agent) 0.015g

[0046] Glycerin (humectant) 1.57g

[0047] Azone (penetration enhancer) 1g

[0048] Propylene glycol (penetration enhancer) 1g

[0049] Deionized water 8.35g

[0050] Preparation:

[0051](1) Drug-containing matrix: add deionized water to the prescribed amount of polyvinylpyrrolidone K90, polyvinylpyrrolidone K30, polyvinyl alcohol-124, aluminum trichloride, and glycerin, heat and stir at 90°C and mix evenly for about 2 hours. Gradually lower the temperature until a gel is formed at room temperature to obtain phase I; completely dissolve lornoxicam with an appropriate amount of DMF,...

Embodiment 2

[0052] Embodiment 2, preparation Lornoxicam hydrogel patch

[0053] Drug-containing matrix components (per 100cm 2 )

[0054] Lornoxicam (main drug) 0.1g

[0055] Polyvinylpyrrolidone K90 (skeleton material) 1.05g

[0056] Polyvinylpyrrolidone K30 (skeleton material) 0.78g

[0057] Polyvinyl alcohol-124 (skeleton material) 0.26g

[0058] Aluminum trichloride (crosslinking agent) 0.015g

[0059] Glycerin (humectant) 1.57g

[0060] Azone (penetration enhancer) 1g

[0061] Propylene glycol (penetration enhancer) 1g

[0062] Deionized water 8.35g

[0063] The preparation method is the same as in Example 1.

Embodiment 3

[0064] Embodiment 3, preparation Lornoxicam hydrogel patch

[0065] Drug-containing matrix components (per 100cm 2 )

[0066] Lornoxicam (main drug) 0.05g

[0067] Polyvinylpyrrolidone K90 (skeleton material) 1.31g

[0068] Polyvinylpyrrolidone K30 (skeleton material) 0.98g

[0069] Polyvinyl alcohol-124 (skeleton material) 0.325g

[0070] Aluminum trichloride (crosslinking agent) 0.018g

[0071] Polyethylene glycol 400 (humectant) 2.12g

[0072] Azone (penetration enhancer) 1g

[0073] Propylene glycol (penetration enhancer) 1g

[0074] Deionized water 10.44g

[0075] The preparation method is the same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention discloses a lornoxicam hydrogel patch and a preparation method thereof. In the hydrogel patch, lornoxicam is used as a medicinal active ingredient, and the hydrogel patch consists of a medicament-containing matrix, an adhesive layer, a lining layer and a protective layer, wherein the medicament-containing matrix consists of the lornoxicam, a hydrogel matrix and a penetrating agent. The patch makes the medicament release stably to prolong half-life period, is remarkably superior to other conventional preparations of the lornoxicam, and has the 48-hour accumulated permeation quantity of over 300ug.cm<-2> through percutaneous experiments in vitro. Pharmacodynamic tests prove that the lornoxicam hydrogel patch has excellent effect of relieving pain and diminishing inflammation.

Description

technical field [0001] The invention relates to a lornoxicam hydrogel patch and a preparation method thereof. Background technique [0002] Lornoxicam (trade name: Kesaifeng) is a non-steroidal anti-inflammatory drug developed by Nycomed, which belongs to thiazide derivatives and has strong analgesic and anti-inflammatory effects. This drug has been widely used clinically for acute pain after surgery, and can also be used for the treatment of chronic low back pain, osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It has been recommended by WHO as the first step drug to control cancer pain. However, the use of most NSAIDs is limited by the side effects associated with them, especially gastrointestinal side effects. Studies have shown that the incidence of adverse drug reactions caused by the application of lornoxicam injection is about 10%, and the main clinical manifestations are nausea, vomiting, stomach pain, diarrhea and other gastrointestinal reactions....

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/542A61K47/32A61K47/34A61K47/36A61K47/38A61P29/00A61K47/10
Inventor 王洪权李理宇兰晶张东娜郭永建李海晶姜洋
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap