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Lornoxicam hydrogel patch and preparation method thereof

A lornoxicam hydrogel patch and technology of lornoxicam, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problems of slow drug release and inability to fully meet clinical needs

Active Publication Date: 2013-04-10
MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this patent uses fat-soluble pressure-sensitive adhesive as the matrix, and the drug release rate is slow, which cannot fully meet the clinical needs

Method used

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  • Lornoxicam hydrogel patch and preparation method thereof
  • Lornoxicam hydrogel patch and preparation method thereof
  • Lornoxicam hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Example 1, preparation of lornoxicam hydrogel patch

[0040] Drug-containing matrix components (per 100cm 2 )

[0041] Lornoxicam (Main Drug) 0.05g

[0042] Polyvinylpyrrolidone K90 (skeleton material) 1.05g

[0043] Polyvinylpyrrolidone K30 (skeleton material) 0.78g

[0044] Polyvinyl alcohol-124 (skeleton material) 0.26g

[0045] Aluminum trichloride (crosslinking agent) 0.015g

[0046] Glycerin (humectant) 1.57g

[0047] Azone (penetration enhancer) 1g

[0048] Propylene glycol (penetration enhancer) 1g

[0049] Deionized water 8.35g

[0050] Preparation:

[0051](1) Drug-containing base: add deionized water to the recipe quantities of polyvinylpyrrolidone K90, polyvinylpyrrolidone K30, polyvinylalcohol-124, aluminum trichloride, and glycerin, and heat and stir at 90°C to mix evenly for about 2 hours. Gradually cool down until it forms a gel at room temperature to obtain phase I; dissolve lornoxicam completely with an appropriate amount of DMF, then add azo...

Embodiment 2

[0052] Example 2, preparation of lornoxicam hydrogel patch

[0053] Drug-containing matrix components (per 100cm 2 )

[0054] Lornoxicam (Main Drug) 0.1g

[0055] Polyvinylpyrrolidone K90 (skeleton material) 1.05g

[0056] Polyvinylpyrrolidone K30 (skeleton material) 0.78g

[0057] Polyvinyl alcohol-124 (skeleton material) 0.26g

[0058] Aluminum trichloride (crosslinking agent) 0.015g

[0059] Glycerin (humectant) 1.57g

[0060] Azone (penetration enhancer) 1g

[0061] Propylene glycol (penetration enhancer) 1g

[0062] Deionized water 8.35g

[0063] The preparation method is the same as in Example 1.

Embodiment 3

[0064] Example 3, preparation of lornoxicam hydrogel patch

[0065] Drug-containing matrix components (per 100cm 2 )

[0066] Lornoxicam (Main Drug) 0.05g

[0067] Polyvinylpyrrolidone K90 (skeleton material) 1.31g

[0068] Polyvinylpyrrolidone K30 (skeleton material) 0.98g

[0069] Polyvinyl alcohol-124 (skeleton material) 0.325g

[0070] Aluminum trichloride (crosslinking agent) 0.018g

[0071] Macrogol 400 (humectant) 2.12g

[0072] Azone (penetration enhancer) 1g

[0073] Propylene glycol (penetration enhancer) 1g

[0074] Deionized water 10.44g

[0075] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a lornoxicam hydrogel patch and a preparation method thereof. In the hydrogel patch, lornoxicam is used as a medicinal active ingredient, and the hydrogel patch consists of a medicament-containing matrix, an adhesive layer, a lining layer and a protective layer, wherein the medicament-containing matrix consists of the lornoxicam, a hydrogel matrix and a penetrating agent. The patch makes the medicament release stably to prolong half-life period, is remarkably superior to other conventional preparations of the lornoxicam, and has the 48-hour accumulated permeation quantity of over 300ug.cm<-2> through percutaneous experiments in vitro. Pharmacodynamic tests prove that the lornoxicam hydrogel patch has excellent effect of relieving pain and diminishing inflammation.

Description

technical field [0001] The invention relates to a lornoxicam hydrogel patch and a preparation method thereof. Background technique [0002] Lornoxicam (trade name Kesaifeng) is a non-steroidal anti-inflammatory drug developed by Nycomed. It is a thiazide derivative with strong analgesic and anti-inflammatory effects. This drug has been widely used clinically for acute pain after surgery, and can also be used for the treatment of chronic low back pain, osteoarthritis, rheumatoid arthritis and ankylosing spondylitis. It has been recommended by WHO as a first-step drug for cancer pain control. However, the use of most NSAIDs is limited by the side effects associated with them, especially gastrointestinal side effects. Studies have shown that the incidence of adverse drug reactions caused by the application of lornoxicam injection is about 10%, and the clinical manifestations are mainly nausea, vomiting, stomach pain, diarrhea and other gastrointestinal reactions. [0003] Co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/70A61K31/542A61K47/32A61K47/34A61K47/36A61K47/38A61P29/00A61K47/10
Inventor 王洪权李理宇兰晶张东娜郭永建李海晶姜洋
Owner MICROBE EPIDEMIC DISEASE INST OF PLA MILITARY MEDICAL ACAD OF SCI
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